دورية أكاديمية
Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity
| العنوان: | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
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| المؤلفون: | Zbigniew Malinowski, Emilia Fornal, Agata Sumara, Renata Kontek, Karol Bukowski, Beata Pasternak, Dariusz Sroczyński, Joachim Kusz, Magdalena Małecka, Monika Nowak |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 558-568 (2021) |
| بيانات النشر: | Beilstein-Institut, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | amination, complexes, cytotoxicity, pd cross-coupling, phthalazinone, Science, Organic chemistry, QD241-441 |
| الوصف: | Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| العلاقة: | https://doaj.org/toc/1860-5397Test |
| DOI: | 10.3762/bjoc.17.50 |
| الوصول الحر: | https://doaj.org/article/51e7c9c7b1e44643944e7b705b8d6d4bTest |
| رقم الانضمام: | edsdoj.51e7c9c7b1e44643944e7b705b8d6d4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.17.50 |