Phenotypic detection and occurrence of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli at a tertiary Hospital in Trinidad & Tobago
| العنوان: | Phenotypic detection and occurrence of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli at a tertiary Hospital in Trinidad & Tobago |
|---|---|
| المؤلفون: | Patrick Eberechi Akpaka, William H. Swanston |
| المصدر: | Brazilian Journal of Infectious Diseases, Volume: 12, Issue: 6, Pages: 516-520, Published: DEC 2008 Brazilian Journal of Infectious Diseases v.12 n.6 2008 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 12, Iss 6, Pp 516-520 |
| بيانات النشر: | Brazilian Society of Infectious Diseases, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Microbiology (medical), E-test methods, Imipenem, Tertiary hospital, Klebsiella pneumoniae, lcsh:QR1-502, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Meropenem, Antimicrobial susceptibility, lcsh:Microbiology, beta-Lactamases, lcsh:Infectious and parasitic diseases, Microbiology, TRINIDAD TOBAGO, E. coli, K. pneumoniae, Escherichia coli, Prevalence, medicine, polycyclic compounds, Humans, lcsh:RC109-216, Trinidad & Tobago, Incidence (epidemiology), biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Enterobacteriaceae, Anti-Bacterial Agents, Phenotype, Trinidad and Tobago, Infectious Diseases, Amikacin, bacteria, ESBL detection, medicine.drug |
| الوصف: | The incidence and distribution of ESBL producing microorganisms such as E. coli and K. pneumoniae have been demonstrated and varies in different health care facilities and as well as other countries This study was carried out to determine the frequency of occurrence and the antimicrobial susceptibility pattern of ESBL producing E. coli and K. pneumoniae species from clinical isolates at a tertiary hospital in Trinidad & Tobago. Standard microbiological procedures and automated MicroScan System was used to identify, screen for putative ESBL production and determine antimicrobial susceptibility of 1,118 clinical isolates of Enterobacteriaceae species at the microbiology laboratory of the Eric Williams Medical Science Complex, Trinidad & Tobago over a 36 months period. All ESBL producing isolates flagged by the automated system were further confirmed by E-test method. The E-test confirmed a 15.2% ESBL rate among the K. pneumoniae isolates and 9.3% among the E. coli isolates. There was also a 1.8% rate of ESBL production in K. pneumoniae and 0.2% in E. coli isolates from specimens received from community health facilities into the laboratory. Isolates recovered from the intensive care unit of the hospital had 2.1% E. coli and 8.2% K. pneumoniae ESBL producers. Although all ESBL positive isolates were completely susceptible to imipenem and meropenem; and all positive K. pneumoniae isolates were susceptible to amikacin, there was a low susceptibility of ESBL positive E. coli to the aminoglycosides. However, susceptibility of these ESBL producing isolates to the fluoroquinolones varied. There is a high rate of ESBL production among isolates of E. coli and K. pneumoniae at this hospital that is linked to the extensive inappropriate use of third generation cephalosporins in the country. Further molecular studies are needed to characterize the types of these ESBL prevailing in the country. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c07226a81b209e39b8a2d8a0bc5d320Test http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600014&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c07226a81b209e39b8a2d8a0bc5d320 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |