Health care-associated native valve endocarditis: importance of non-nosocomial acquisition
| العنوان: | Health care-associated native valve endocarditis: importance of non-nosocomial acquisition |
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| المؤلفون: | Benito N, Miró JM, de Lazzari E, Cabell CH, del Río A, Altclas J, Commerford P, Delahaye F, Dragulescu S, Giamarellou H, Habib G, Kamarulzaman A, Kumar AS, Nacinovich FM, Suter F, Tribouilloy C, Venugopal K, Moreno A, Fowler VG Jr, among ICE PCS Investigators, UTILI, Riccardo |
| المساهمون: | Humbert, Murielle, Benito, N, Miró, Jm, de Lazzari, E, Cabell, Ch, del Río, A, Altclas, J, Commerford, P, Delahaye, F, Dragulescu, S, Giamarellou, H, Habib, G, Kamarulzaman, A, Kumar, A, Nacinovich, Fm, Suter, F, Tribouilloy, C, Venugopal, K, Moreno, A, Fowler VG, Jr, among ICE PCS, Investigator, Utili, Riccardo |
| المصدر: | Europe PubMed Central ResearcherID Flinders University PURE |
| بيانات النشر: | ACP ASIM / American College of Physicians:190 North Independence Mall West:Philadelphia, PA 19106:(800)523-1546, (215)351-2600, EMAIL: custserv@mail.acponline.org, INTERNET: http://www.acponline.orgTest, Fax: (215)351-2799, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Article, Ambulatory care, Renal Dialysis, Risk Factors, Health care, Epidemiology, Internal Medicine, medicine, Ambulatory Care, Endocarditis, Humans, Prospective Studies, Intensive care medicine, Aged, Ultrasonography, Native Valve Endocarditis, Cross Infection, business.industry, Public health, nosocomial, General Medicine, Endocarditis, Bacterial, Middle Aged, medicine.disease, Cardiac surgery, Community-Acquired Infections, Treatment Outcome, Endocarditis, nosocomial, S.aureus, S.aureus, Bacteremia, endocarditis, health-care associated infections, Female, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business |
| الوصف: | BACKGROUND: The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined. OBJECTIVE: To compare the characteristics and outcomes of community-associated and nosocomial and non-nosocomial health care-associated native valve endocarditis. DESIGN: Prospective cohort study. SETTING: 61 hospitals in 28 countries. PATIENTS: Patients with definite native valve endocarditis and no history of injection drug use who were enrolled in the ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) from June 2000 to August 2005. MEASUREMENTS: Clinical and echocardiographic findings, microbiology, complications, and mortality. RESULTS: Health care-associated native valve endocarditis was present in 557 (34%) of 1622 patients (303 with nosocomial infection [54%] and 254 with non-nosocomial infection [46%]). Staphylococcus aureus was the most common cause of health care-associated infection (nosocomial, 47%; non-nosocomial, 42%; P = 0.30); a high proportion of patients had methicillin-resistant S. aureus (nosocomial, 57%; non-nosocomial, 41%; P = 0.014). Fewer patients with health care-associated native valve endocarditis had cardiac surgery (41% vs. 51% of community-associated cases; P < 0.001), but more of the former patients died (25% vs. 13%; P < 0.001). Multivariable analysis confirmed greater mortality associated with health care-associated native valve endocarditis (incidence risk ratio, 1.28 [95% CI, 1.02 to 1.59]). LIMITATIONS: Patients were treated at hospitals with cardiac surgery programs. The results may not be generalizable to patients receiving care in other types of facilities or to those with prosthetic valves or past injection drug use. CONCLUSION: More than one third of cases of native valve endocarditis in non-injection drug users involve contact with health care, and non-nosocomial infection is common, especially in the United States. Clinicians should recognize that outpatients with extensive out-of-hospital health care contacts who develop endocarditis have clinical characteristics and outcomes similar to those of patients with nosocomial infection. PRIMARY FUNDING SOURCE: None. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6319968f1d515a850f939e47a674ef1Test http://hdl.handle.net/11386/3104450Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d6319968f1d515a850f939e47a674ef1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |