نتائج البحث

1

دورية أكاديمية

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models

المؤلفون: Melanie Das, Wenjie Mao, Yuliya Voskobiynyk, Deanna Necula, Irene Lew, Cathrine Petersen, Allie Zahn, Gui-Qiu Yu, Xinxing Yu, Nicholas Smith, Faten A. Sayed, Li Gan, Jeanne T. Paz, Lennart Mucke

المصدر: Neurobiology of Disease, Vol 186, Iss , Pp 106263- (2023)

مصطلحات موضوعية: Alzheimer's disease, Amyloid precursor protein, EEG, Epilepsy, Glia, Hyperexcitability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996123002784Test; https://doaj.org/toc/1095-953XTest; https://doaj.org/article/4987e0ad25dc4d4582c691bc3ce7b459Test

الإتاحة: https://doi.org/10.1016/j.nbd.2023.106263Test
https://doaj.org/article/4987e0ad25dc4d4582c691bc3ce7b459Test

View record in BASE

النص الكامل

2

دورية أكاديمية

Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony

المؤلفون: Che-Wei Chang, Mark D. Evans, Xinxing Yu, Gui-Qiu Yu, Lennart Mucke

المصدر: Cell Reports, Vol 37, Iss 3, Pp 109855- (2021)

مصطلحات موضوعية: Alzheimer’s disease, axon initial segment, epilepsy, excitation-inhibition balance, hypersynchrony, interneurons, Biology (General), QH301-705.5

العلاقة: http://www.sciencedirect.com/science/article/pii/S221112472101322XTest; https://doaj.org/toc/2211-1247Test; https://doaj.org/article/73db2489088f4c478eec50f3c9451794Test

الإتاحة: https://doi.org/10.1016/j.celrep.2021.109855Test
https://doaj.org/article/73db2489088f4c478eec50f3c9451794Test

View record in BASE

النص الكامل

3

دورية أكاديمية

Additional file of Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

المؤلفون: Erik C. B. Johnson (8912864), Kaitlyn Ho (132571), Gui-Qiu Yu (132580), Melanie Das (9372562), Pascal E. Sanchez (9372565), Biljana Djukic (4037498), Isabel Lopez (4740315), Xinxing Yu (9372568), Michael Gill (195307), Weiping Zhang (311523), Jeanne T. Paz (9372571), Jorge J. Palop (5063843), Lennart Mucke (9372574)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Developmental Biology, Mental Health, Alzheimer’s disease, Amyloid, APP, APP-KI, AppNL-G-F, BACE, Behavior, Calbindin, C-Fos, Epilepsy, Epileptiform, I5, Inhibitor, J20, Knock-in, Learning and memory, Oligomers, SWD

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_of_Behavioral_and_neural_network_abnormalities_in_human_APP_transgenic_mice_resemble_those_of_App_knock-in_mice_and_are_modulated_by_familial_Alzheimer_s_disease_mutations_but_not_by_inhibition_of_BACE1/14433572Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14433572.v1Test

View record in BASE

4

دورية أكاديمية

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

المؤلفون: Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke

المصدر: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-26 (2020)

مصطلحات موضوعية: Alzheimer’s disease, Amyloid, APP, APP-KI, App NL-G-F, BACE, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

العلاقة: http://link.springer.com/article/10.1186/s13024-020-00393-5Test; https://doaj.org/toc/1750-1326Test; https://doaj.org/article/241e604b9e154d01b93f232dcc4d0aa4Test

الإتاحة: https://doi.org/10.1186/s13024-020-00393-5Test
https://doaj.org/article/241e604b9e154d01b93f232dcc4d0aa4Test

View record in BASE

النص الكامل

5

دورية أكاديمية

Neuronal levels and sequence of tau modulate the power of brain rhythms

المؤلفون: Melanie Das, Sumihiro Maeda, Bozhong Hu, Gui-Qiu Yu, Weikun Guo, Isabel Lopez, Xinxing Yu, Chao Tai, Xin Wang, Lennart Mucke

المصدر: Neurobiology of Disease, Vol 117, Iss , Pp 181-188 (2018)

مصطلحات موضوعية: A152T, Alzheimer's disease, Biomarker, Brain rhythms, EEG, Epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

العلاقة: http://www.sciencedirect.com/science/article/pii/S096999611830158XTest; https://doaj.org/toc/1095-953XTest; https://doaj.org/article/2e833ca75e0e4c69909fd62cdfa1e395Test

الإتاحة: https://doi.org/10.1016/j.nbd.2018.05.020Test
https://doaj.org/article/2e833ca75e0e4c69909fd62cdfa1e395Test

View record in BASE

6

دورية أكاديمية

Istradefylline reduces memory deficits in aging mice with amyloid pathology

المؤلفون: Anna G. Orr, Iris Lo, Heike Schumacher, Kaitlyn Ho, Michael Gill, Weikun Guo, Daniel H. Kim, Anthony Knox, Takashi Saito, Takaomi C. Saido, Jeffrey Simms, Carlee Toddes, Xin Wang, Gui-Qiu Yu, Lennart Mucke

المصدر: Neurobiology of Disease, Vol 110, Iss , Pp 29-36 (2018)

مصطلحات موضوعية: Adenosine receptors, Alzheimer's disease, Amyloid plaques, Antagonist, Astrocytes, Behavior, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996117302413Test; https://doaj.org/toc/1095-953XTest; https://doaj.org/article/62158c22ffd34e74b78e39a026e12011Test

الإتاحة: https://doi.org/10.1016/j.nbd.2017.10.014Test
https://doaj.org/article/62158c22ffd34e74b78e39a026e12011Test

View record in BASE

7

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

المؤلفون: Jiaming Wang, Xinxing Yu, Lennart Mucke, Xin Wang, Kaitlyn Ho, Gui-Qiu Yu, Wenjie Mao, Soniya Tamhankar, Eric Shao, Melanie Das

المصدر: iScience, Vol 24, Iss 11, Pp 103245-(2021)
iScience, vol 24, iss 11
iScience

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b693775485c3346960378beab64d21Test
http://www.sciencedirect.com/science/article/pii/S258900422101213XTest

8

دورية أكاديمية

p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer's disease.

المؤلفون: Li, Jia-Bing, Hu, Xiao-Yu, Chen, Mu-Wen, Xiong, Cai-Hong, Zhao, Na, Ge, Yan-Hui, Wang, Hao, Gao, Xiao-Ling, Xu, Nan-Jie, Zhao, Lan-Xue, Yu, Zhi-Hua, Chen, Hong-Zhuan, Qiu, Yu

المصدر: Translational Neurodegeneration; 1/9/2023, Vol. 12 Issue 1, p1-18, 18p

مصطلحات موضوعية: ALZHEIMER'S disease, AMPA receptors, RIBOSOMAL proteins, COGNITIVE ability, SPATIAL memory, LONG-term synaptic depression

النص الكامل

9

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

المصدر: Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Elsevier
Cell reports, vol 30, iss 2
Cell reports

مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Male, Aging, Medical Physiology, Epilepsies, Myoclonic, Electroencephalography, Epilepsies, Neurodegenerative, Inbred C57BL, Alzheimer's Disease, memory, Epilepsy, Mice, 0302 clinical medicine, Cognition, Receptors, 2.1 Biological and endogenous factors, EEG, SCN1A, Aetiology, lcsh:QH301-705.5, MK-801, learning, Behavior, Animal, medicine.diagnostic_test, musculoskeletal, neural, and ocular physiology, Brain, medicine.anatomical_structure, Neurological, NMDA receptor, Mental health, N-Methyl-D-Aspartate, Allosteric modulator, Interneuron, Intellectual and Developmental Disabilities (IDD), Allosteric regulation, CHO Cells, interneuron, Receptors, N-Methyl-D-Aspartate, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Cricetulus, Dravet syndrome, Allosteric Regulation, Alzheimer Disease, Nitriles, Behavioral and Social Science, medicine, Acquired Cognitive Impairment, Animals, Humans, Behavior, business.industry, Animal, Nav1.1, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), medicine.disease, Brain Disorders, Mice, Inbred C57BL, Disease Models, Animal, Thiazoles, 030104 developmental biology, nervous system, lcsh:Biology (General), Disease Models, Pyrazoles, epilepsy, Dementia, Biochemistry and Cell Biology, J20, business, Myoclonic, APP, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0ddfb3fdc3d2e4aa7d6b4342a59d2Test
http://www.sciencedirect.com/science/article/pii/S2211124719316808Test

10

Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice

المؤلفون: Xinxing Yu, Gui-Qiu Yu, Daniel Kim, Melanie Das, Eric Shao, Kaitlyn Ho, Weiping J. Zhang, Lennart Mucke, Daniel R. Gulbranson, Reuben Thomas, Krishna Choudhary

المصدر: eNeuro
eNeuro, vol 8, iss 3

مصطلحات موضوعية: Genetically modified mouse, Aging, Knockout, mouse model, Mice, Transgenic, amyloid precursor protein, Biology, Neurodegenerative, Alzheimer's Disease, Transgenic, Pathogenesis, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Amyloid precursor protein, Genetics, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Animals, Allele, Gene, Mice, Knockout, Amyloid beta-Peptides, Animal, behavior, General Neuroscience, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), General Medicine, Phenotype, Brain Disorders, Disease Models, Animal, Knockout mouse, Disease Models, Neurological, biology.protein, epilepsy, Dementia, Disorders of the Nervous System, Zbtb20, Neural development, Alzheimer’s disease, Research Article: New Research, Biotechnology, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f50258965b6bdb56bcafc1d3df1ce8aTest
http://europepmc.org/articles/PMC8121260Test

تنقيح النتائج