المؤلفون: Silva, Daniel, Mendes, Eduarda, Summers, Eleanor J., Neca, Ana, Jacinto, Ana C., Reis, Telma, Agostinho, Paula, Bolea, Irene, Jimeno, M. Luisa, Mateus, M. Luisa, Oliveira-Campos, Ana M. F., Unzeta, Mercedes, Marco-Contelles, José, Majekova, Magdalena, Ramsay, Rona R., Carreiras, M. Carmo

المصدر: Silva , D , Mendes , E , Summers , E J , Neca , A , Jacinto , A C , Reis , T , Agostinho , P , Bolea , I , Jimeno , M L , Mateus , M L , Oliveira-Campos , A M F , Unzeta , M , Marco-Contelles , J , Majekova , M , Ramsay , R R & Carreiras , M C 2019 , ' Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds : exploring multiple activities as anti-Alzheimer agents ' , Drug Development Research , vol. Early View ....

مصطلحات موضوعية: Nitrile-containing compounds, Alzheimer's disease, MAO inhibitors, Cholinesterase inhibitors, Aβ1-42 disaggregating agents, In silico study

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/synthesis-biological-evaluation-and-molecular-modeling-of-nitrilecontaining-compoundsTest(a2bf3daa-a7f7-4a16-9729-e4ef09695e3a).html

الإتاحة: https://doi.org/10.1002/ddr.21594Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/synthesis-biological-evaluation-and-molecular-modeling-of-nitrilecontaining-compoundsTest(a2bf3daa-a7f7-4a16-9729-e4ef09695e3a).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/20525/1/Silva2019acceptedDDR.pdfTest

المؤلفون: Marco-Contelles, José, Unzeta López, Mercedes, Bolea Tomás, Irene, Esteban, Gerard, Ramsay, Rona R., Romero, Alejandro, Martínez-Murillo, Ricard, Carreiras, M. Carmo, Ismaili, Lhassane

مصطلحات موضوعية: Multi-target directed ligands, Alzheimer's disease, Monoamine oxidases, Cholinesterases, Drugs

وصف الملف: application/pdf

العلاقة: Ministerio de Economía y Competitividad SAF2015-65586-R; Ministerio de Economía y Competitividad SAF2012-33304; Frontiers in Neuroscience; Vol. 10 (june 2016); https://ddd.uab.cat/record/254185Test; urn:10.3389/fnins.2016.00294; urn:oai:ddd.uab.cat:254185; urn:pmcid:PMC4923252; urn:pmc-uid:4923252; urn:pmid:27445665; urn:oai:pubmedcentral.nih.gov:4923252; urn:oai:egreta.uab.cat:publications/72bbe300-6fca-4ea6-b86c-203697aee8bd; urn:scopus_id:84980396145

الإتاحة: https://ddd.uab.cat/record/254185Test

المؤلفون: Silva, Daniel, Mendes, Eduarda, Summers, Eleanor J., Neca, Ana, Jacinto, Ana C., Reis, Telma, Agostinho, Paula, Bolea, Irene, Jimeno, M. Luisa, Mateus, M. Luisa, Oliveira-Campos, Ana M. F., Unzeta, Mercedes, Marco-Contelles, José, Majekova, Magdalena, Ramsay, Rona R., Carreiras, M. Carmo

المساهمون: University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. School of Biology

مصطلحات موضوعية: Nitrile-containing compounds, Alzheimer's disease, MAO inhibitors, Cholinesterase inhibitors, Aβ1-42 disaggregating agents, In silico study, RM Therapeutics. Pharmacology, NDAS, RM

وصف الملف: application/pdf

العلاقة: Drug Development Research; 260556740; a2bf3daa-a7f7-4a16-9729-e4ef09695e3a; 85071395167; 000484141800001; Silva , D , Mendes , E , Summers , E J , Neca , A , Jacinto , A C , Reis , T , Agostinho , P , Bolea , I , Jimeno , M L , Mateus , M L , Oliveira-Campos , A M F , Unzeta , M , Marco-Contelles , J , Majekova , M , Ramsay , R R & Carreiras , M C 2019 , ' Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds : exploring multiple activities as anti-Alzheimer agents ' , Drug Development Research , vol. Early View , DDR-19-0121.R1 . https://doi.org/10.1002/ddr.21594Test; ORCID: /0000-0003-1535-4904/work/61369941; https://hdl.handle.net/10023/20525Test

الإتاحة: https://doi.org/10.1002/ddr.21594Test
https://hdl.handle.net/10023/20525Test

المؤلفون: Dgachi, Youssef, Martin, H., Martin, Hélène, Malek, R, Jun, D., Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Maalej, Enma, Carreiras, M. Carmo, Refouvelet, B., Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane

المساهمون: Ministerio de Economía, Industria y Competitividad (España), European Commission

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.drug_class, Short Communication, tacrine, Pharmacology, 01 natural sciences, Neuroprotection, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Kojic acid, Drug Discovery, medicine, alzheimer disease, Humans, Structure–activity relationship, IC50, Dose-Response Relationship, Drug, Molecular Structure, kojic acid, 010405 organic chemistry, business.industry, lcsh:RM1-950, General Medicine, multitarget small molecules, medicine.disease, Acetylcholinesterase, Multitarget small molecules, 0104 chemical sciences, Neuroprotective Agents, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, Acetylcholinesterase inhibitor, Drug Design, Tacrine, Cholinesterase Inhibitors, Alzheimer's disease, Alzheimer disease, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f01cc1d23157fa3d81d0133cfe5701Test
http://hdl.handle.net/10261/175021Test

المؤلفون: Martins C., Carreiras M. C., Leon R., de Los Rios C., Iriepa I., Moraleda I., Galvez E., Garcia M., Egea J., Samadi A., Chioua M., Marco Contelles J., BARTOLINI, MANUELA, ANDRISANO, VINCENZA

المساهمون: Martins C., Carreiras M. C., Leon R., de Los Rios C., Bartolini M., Andrisano V., Iriepa I., Moraleda I., Galvez E., Garcia M., Egea J., Samadi A., Chioua M., Marco-Contelles J.

مصطلحات موضوعية: ACHE/BUCHE INHIBITORS, NEUROPROTECTION, ALZHEIMER’S DISEASE

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22000936; info:eu-repo/semantics/altIdentifier/wos/WOS:000297874300044; volume:46; issue:12; firstpage:6119; lastpage:6130; numberofpages:12; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11585/107875Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-80955140466; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22000936Test

الإتاحة: https://doi.org/10.1016/j.ejmech.2011.09.038Test
http://hdl.handle.net/11585/107875Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22000936Test

المؤلفون: Carreiras, M. Carmo, Mendes, Eduardo, Perry, M. Jesús, Francisco, Ana Paula, Marco-Contelles, José

مصطلحات موضوعية: oxidative stress, metal chelators, MAO, Dual AChE/BuChE inhibitors, ChEs, Ca2+ dishomeostasis, Aβ, Alzheimer's disease

العلاقة: e-issn: 1873-4294; Current Topics in Medicinal Chemistry 13: 1745-1770 (2013); http://hdl.handle.net/10261/112859Test

الإتاحة: https://doi.org/10.2174/15680266113139990135Test
http://hdl.handle.net/10261/112859Test

المؤلفون: Silva, Daniel, Chioua, Mourad, Samadi, Abdelouahid, Agostinho, Paula, Garção, Pedro, Lajarín-Cuesta, Rocío, Ríos, Cristobal de los, Iriepa, Isabel, Moraleda, Ignacio, González-Lafuente, Laura, Mendes, Eduarda, Pérez, Concepción, Rodríguez-Franco, María Isabel, Marco-Contelles, José, Carreiras, M. Carmo

مصطلحات موضوعية: neuroprotection, Aβ peptide, AChE/BuChE inhibitors, Ca2+ dyshomeostasis, Alzheimer’s disease, quinolinodonepezils, Pyridonepezils

العلاقة: e-issn: 1948-7193; ACS Chemical Neuroscience 4: 547- 565 (2013); http://hdl.handle.net/10261/103634Test

الإتاحة: https://doi.org/10.1021/cn300178kTest
http://hdl.handle.net/10261/103634Test

المؤلفون: Silva, Daniel^1,2, Chioua, Mourad², Samadi, Abdelouahid², Carmo Carreiras, M.¹ iqoc21@iqog.csic.es, Jimeno, María-Luisa³, Mendes, Eduarda¹, Ríos, Cristóbal de los^4,5, Romero, Alejandro^6,7, Villarroya, Mercedes^4,6, López, Manuela G.^6,8, Marco-Contelles, José² mcdamaso@ff.ul.pt

المصدر: European Journal of Medicinal Chemistry. Sep2011, Vol. 46 Issue 9, p4676-4681. 6p.

مصطلحات موضوعية: *ORGANIC synthesis, *PQQ (Biochemistry), *NAPHTHYRIDINES, *ACETYLCHOLINESTERASE, *OXIDATIVE stress, *ALZHEIMER'S disease treatment, *ENZYME inhibitors

المؤلفون: Ignacio Moraleda, Rafael León, Manuela García, M. Carmo Carreiras, Vincenza Andrisano, Carla Martins, Cristóbal de los Ríos, Enrique Gálvez, José Marco-Contelles, Abdelouhaid Samadi, Javier Egea, Mourad Chioua, Manuela Bartolini, Isabel Iriepa

المساهمون: Martins C., Carreiras M. C., Leon R., de Los Rios C., Bartolini M., Andrisano V., Iriepa I., Moraleda I., Galvez E., Garcia M., Egea J., Samadi A., Chioua M., Marco-Contelles J.

المصدر: European journal of medicinal chemistry. 46(12)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, ACHE/BUCHE INHIBITORS, chemistry.chemical_compound, Alzheimer Disease, Drug Discovery, medicine, Humans, Butyrylcholinesterase, Cholinesterase, Pharmacology, chemistry.chemical_classification, NEUROPROTECTION, biology, ALZHEIMER’S DISEASE, Organic Chemistry, Active site, General Medicine, Acetylcholinesterase, Enzyme, chemistry, Docking (molecular), Tacrine, biology.protein, Aminoquinolines, Amine gas treating, Cholinesterase Inhibitors, medicine.drug

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af52204ef77d6ab74f638461fa32ff0Test
https://pubmed.ncbi.nlm.nih.gov/22000936Test