التفاصيل البيبلوغرافية
| العنوان: |
Intercalation of Anti-inflammatory Drugs Sodium Indomethacin into Nanocomposites of Mg-Al. Structural Characterization. |
| المؤلفون: |
Mendieta, S., Nuñez, P. Reyes, Oliva, M., Pérez, C., Fernández, J., Crivello, M. |
| المصدر: |
Procedia Materials Science; Jan2012, Vol. 1, p580-587, 8p |
| مصطلحات موضوعية: |
ANTI-inflammatory agents, CLATHRATE compounds, SODIUM compounds, NANOCOMPOSITE materials, ALUMINUM-magnesium alloys, LAYERED double hydroxides, PHARMACEUTICAL industry |
| مستخلص: |
Abstract: Layered double hydroxides (LDH) have many applications as matrices in pharmaceutical fields. γ-Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and the salt Sodium Indomethacin (INDONa) have been used as host drugs to be intercalated into LDH. As consequence of salt formation a polymorph of indomethacin was obtained. Intercalated compound was prepared via ion exchange and co-precipitation. As consequence of the intercalation, the interlayer distance of the host increased. The NSAID and LDH-INDONa were characterized by XRD, FT-IR and drug content was determinate by UV spectroscopy. The highest percentage of INDONa load was observed in the LDH-CI incorporated by direct method (48.40 wt%). [Copyright &y& Elsevier] |
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