دورية أكاديمية
Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease
| العنوان: | Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease |
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| المؤلفون: | Elbini-Dhouib, Ines, Doghri, Raoudha, Ellefi, Amenallah, Degrach, Imen, Srairi-Abid, Najet, Gati, Asma |
| المساهمون: | Biomolécules, Venins et Applications Théranostiques Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Salah Azaiz Tunis (ISA), Animalerie Tunis, Université de Tunis El Manar (UTM), This work was financed and supported by the Tunisian Ministry of Higher Education and Scientific Research (LR20IPT01). |
| المصدر: | ISSN: 1420-3049 ; Molecules ; https://riip.hal.science/pasteur-03548966Test ; Molecules, 2021, 26 (10), pp.3011. ⟨10.3390/molecules26103011⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Réseau International des Instituts Pasteur, Paris: HAL-RIIP |
| مصطلحات موضوعية: | antioxidant, anti-inflammatory, neuroprotective, aluminum, MESH: Acetylcholinesterase, MESH: Aluminum Chloride, MESH: Cytokines, MESH: Disease Models, Animal, MESH: Hippocampus, MESH: Inflammation, MESH: Inflammation Mediators, MESH: Male, MESH: Nerve Degeneration, MESH: Neuroprotective Agents, MESH: Neurotoxicity Syndromes, MESH: Organ Size, MESH: Alzheimer Disease, MESH: Oxidative Stress, MESH: Rats, Wistar, MESH: Animals, MESH: Anxiety, MESH: Apoptosis, MESH: Body Weight, MESH: Cell Survival, MESH: Cognitive Dysfunction, MESH: Curcumin, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Despite research efforts, currently there are no effective pharmacotherapeutic options for the prevention and treatment of AD. Recently, numerous studies highlighted the beneficial effects of curcumin (CUR), a natural polyphenol, in the neuroprotection. Especially, its dual antioxidant and anti-inflammatory properties attracted the interest of researchers. In fact, besides its antioxidant and anti-inflammatory properties, this biomolecule is not degraded in the intestinal tract. Additionally, CUR is able to cross the blood–brain barrier and could therefore to be used to treat neurodegenerative pathologies associated with oxidative stress, inflammation and apoptosis. The present study aimed to assess the ability of CUR to induce neuronal protective and/or recovery effects on a rat model of neurotoxicity induced by aluminum chloride (AlCl3), which mimics the sporadic form of Alzheimer’s disease. Our results showed that treatment with CUR enhances pro-oxidant levels, antioxidant enzymes activities and anti-inflammatory cytokine production and decreases apoptotic cells in AlCl3-exposed hippocampus rats. Additionally, histopathological analysis of hippocampus revealed the potential of CUR in decreasing the hallmarks in the AlCl3-induced AD. We also showed that CUR post-treatment significantly improved the behavioral, oxidative stress and inflammation in AlCl3-exposed rats. Taken together, our data presented CUR as a nutraceutical potential through its protective effects that are more interesting than recovery ones in sporadic model of AD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34070220; pasteur-03548966; https://riip.hal.science/pasteur-03548966Test; https://riip.hal.science/pasteur-03548966/documentTest; https://riip.hal.science/pasteur-03548966/file/molecules-26-03011.pdfTest; PUBMED: 34070220; PUBMEDCENTRAL: PMC8158738 |
| DOI: | 10.3390/molecules26103011 |
| الإتاحة: | https://doi.org/10.3390/molecules26103011Test https://riip.hal.science/pasteur-03548966Test https://riip.hal.science/pasteur-03548966/documentTest https://riip.hal.science/pasteur-03548966/file/molecules-26-03011.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.21A889B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/molecules26103011 |
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