The Biomarkers for Preterm Birth Study—A prospective observational study comparing the impact of vaginal biomarkers on clinical practice when used in women with symptoms of preterm labor
| العنوان: | The Biomarkers for Preterm Birth Study—A prospective observational study comparing the impact of vaginal biomarkers on clinical practice when used in women with symptoms of preterm labor |
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| المؤلفون: | Katie M. Groom, Ying Huang, Lucy Prentice, Lisa Dawes |
| المصدر: | Acta Obstetricia et Gynecologica Scandinavica. 99:249-258 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Preterm labor, 03 medical and health sciences, Obstetric Labor, Premature, 0302 clinical medicine, Standard care, Predictive Value of Tests, Pregnancy, Alpha-Globulins, medicine, Humans, Prospective Studies, 030212 general & internal medicine, 030219 obstetrics & reproductive medicine, Fetal fibronectin, business.industry, Obstetrics, Obstetrics and Gynecology, General Medicine, medicine.disease, Fibronectins, Clinical Practice, Premature birth, Vagina, Premature Birth, Biomarker (medicine), Gestation, Female, Observational study, business, Biomarkers, New Zealand |
| الوصف: | INTRODUCTION This study aims to compare the use of qualitative fetal fibronectin, quantitative fetal fibronectin, and placental α-microglobulin-1 in women with symptoms of preterm labor, to evaluate which vaginal biomarker performs the best in clinical practice. MATERIAL AND METHODS This prospective observational study included women who presented with symptoms of preterm labor at 24+0 to 34+0 weeks of gestation at a large tertiary maternity hospital in Auckland, New Zealand. Women were managed according to hospital guidelines using qualitative fetal fibronectin. Quantitative fetal fibronectin and placental α-microglobulin-1 tests were also taken, with clinicians blinded to the results. Management and delivery outcomes were collected from clinical records. The primary outcome was the rate of antenatal hospital admission. Analysis was performed according to predefined management protocols for each of the tests. RESULTS A total of 128 women had all three biomarkers tests taken. Spontaneous preterm birth rates were 7/128 (5.5%) ≤34+0 weeks and 20/128 (15.6%) |
| تدمد: | 1600-0412 0001-6349 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3465093e85d61340ddb92394f10089e0Test https://doi.org/10.1111/aogs.13729Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3465093e85d61340ddb92394f10089e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000412 00016349 |
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