دورية أكاديمية
A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application
| العنوان: | A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application |
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| المؤلفون: | Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 5, p 2441 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | alpha-1 antitrypsin, alpha-1 antitrypsin deficiency, proteases, cytokines, interleukin-6, complement C3, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surface interactions. AAT contains a reactive methionine residue that is critical for its protease-specific binding capacity, whereby AAT entraps the protease on cleavage of its reactive centre loop, neutralises its activity by key changes in its tertiary structure, and permits removal of the AAT-protease complex from the circulation. Recently, however, the immunomodulatory role of AAT has come increasingly to the fore with several prominent studies focused on lipid or protein-protein interactions that are predominantly mediated through electrostatic, glycan, or hydrophobic potential binding sites. The aim of this review was to investigate the spectrum of AAT molecular interactions, with newer studies supporting a potential therapeutic paradigm for AAT augmentation therapy in disorders in which a chronic immune response is strongly linked. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/23/5/2441Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms23052441 |
| الوصول الحر: | https://doaj.org/article/e95866bc15ba4f818cf757bd848d6ef5Test |
| رقم الانضمام: | edsdoj.95866bc15ba4f818cf757bd848d6ef5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23052441 |