Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients
| العنوان: | Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients |
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| المؤلفون: | Claire Bewshea, James R Goodhand, Peter Kelleher, Nick Powell, Rachel L Griffiths, Nicholas A. Kennedy, Philip J Smith, Shaji Sebastian, Arkir Zehra, Bessie Cipriano, Desmond Chee, Louise Greathead, Benjamin Hamilton, Simeng Lin, Rachel Nice, Lauranne A A P Derikx, Neil Chanchlani, Hajir Ibraheim, Peter M. Irving, Klaartje Kok, Charlie W. Lees, Jonathan Macdonald, Timothy J. McDonald, Allan Dunlop, Tariq Ahmad |
| المصدر: | Journal of Crohn's and Colitis, 16, 3, pp. 389-397 Journal of Crohn's & Colitis Journal of Crohn's and Colitis, 16, 389-397 Chanchlani, N, Lin, S, Chee, D, Hamilton, B, Nice, R, Arkir, Z, Bewshea, C, Cipriano, B, Derikx, L A A P, Dunlop, A, Greathead, L, Griffiths, R L, Ibraheim, H, Kelleher, P, Kok, K B, Lees, C W, MacDonald, J, Sebastian, S, Smith, P J, McDonald, T J, Irving, P M, Powell, N, Kennedy, N A, Goodhand, J R & Ahmad, T 2022, ' Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses : Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients ', Journal of Crohn's & colitis, vol. 16, no. 3, pp. 389-397 . https://doi.org/10.1093/ecco-jcc/jjab153Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, TNF, Gastroenterology, Serology, Seroepidemiologic Studies, adalimumab, skin and connective tissue diseases, immunosuppression, biology, medicine.diagnostic_test, General Medicine, Eccojc/1020, Original Article, Drug Monitoring, Antibody, Life Sciences & Biomedicine, biologic, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], medicine.drug, vedolizumab, Adult, medicine.medical_specialty, Combination therapy, MATURATION, Vedolizumab, DEFICIENT, inflammatory bowel disease, Internal medicine, Adalimumab, medicine, Humans, Seroprevalence, AcademicSubjects/MED00260, Biological Products, Science & Technology, Gastroenterology & Hepatology, SARS-CoV-2, business.industry, COVID-19, 1103 Clinical Sciences, vaccination, Inflammatory Bowel Diseases, Infliximab, ALPHA, Therapeutic drug monitoring, CLARITY, Antibody Formation, biology.protein, Tumor Necrosis Factor Inhibitors, infliximab, business, INFLAMMATORY-BOWEL-DISEASE |
| الوصف: | Background and Aims Infliximab attenuates serological responses to SARS-CoV-2 infection. Whether this is a class effect, or if anti-tumour necrosis factor [anti-TNF] level influences serological responses, remains unknown. Methods Seroprevalence and the magnitude of SARS-CoV-2 nucleocapsid antibody responses were measured in surplus serum from 11 422 (53.3% [6084] male; median age 36.8 years) patients with immune-mediated inflammatory diseases, stored at six therapeutic drug monitoring laboratories between January 29 and September 30, 2020. Data were linked to nationally held SARS-CoV-2 PCR results to July 11, 2021. Results Rates of PCR-confirmed SARS-CoV-2 infection were similar across treatment groups. Seroprevalence rates were lower in infliximab- and adalimumab- than vedolizumab-treated patients (infliximab: 3.0% [178/5893], adalimumab: 3.0% [152/5074], vedolizumab: 6.7% [25/375], p = 0.003). The magnitude of SARS-CoV-2 reactivity was similar in infliximab- vs adalimumab-treated patients (median 4.30 cut-off index [COI] [1.94–9.96] vs 5.02 [2.18–18.70], p = 0.164), but higher in vedolizumab-treated patients (median 21.60 COI [4.39–68.10, p Conclusion Anti-TNF treatment is associated with lower SARS-CoV-2 nucleocapsid seroprevalence and antibody reactivity when compared to vedolizumab-treated patients. Higher seropositivity rates in patients with undetectable anti-TNF levels support a causal relationship, although confounding factors, such as combination therapy with a immunomodulator, may have influenced the results. |
| وصف الملف: | application/pdf |
| تدمد: | 1873-9946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c08447d7329ab51228946a10f8ee899Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6c08447d7329ab51228946a10f8ee899 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18739946 |
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