FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
| العنوان: | FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA |
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| المؤلفون: | N. A. Sinelnikova, N. V. Bychkova, N. M. Kalinina |
| المصدر: | Medicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 39-46 (2015) |
| بيانات النشر: | SPb RAACI, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Allergy, Exacerbation, Immunology, chemical and pharmacologic phenomena, Disease, Immunoglobulin E, chronic urticaria, Immune system, immune system diseases, parasitic diseases, medicine, Immunology and Allergy, skin and connective tissue diseases, Chronic urticaria, biology, type 2 t-helper cells, business.industry, cd203c, Atopic dermatitis, RC581-607, medicine.disease, Dermatology, Basophil activation, biology.protein, ige, Immunologic diseases. Allergy, business, basophils |
| الوصف: | Some features of peripheral bood basophil activation were studied in children with different types of chronic urticaria, in order to specify the sustaining mechanisms of chronic urticaria. This study presents comparative data concerning spontaneous basophil activation, IgE level and Th2 helper cells. We observed forty-seven children with chronic urticaria, seventy children with exacerbated atopic dermatitis with different disease severity, fifteen healthy children without signs of allergy, or pseudo-allergy. High degree of the basophil activation was detected in children with exacerbation of atopic dermatitis (a comparison group), which was different from the groups of healthy children and patients with chronic urticaria. Spontaneous basophile activation was higher in children with chronic urticaria than in healthy children, as influenced by immune and non-immune pathogenetic factors of the disease. A positive pairwise correlation was shown between total IgE level, and Th2 helper cell numbers in peripheral blood in patients with chronic urticaria, thus confirming a Th2 immune shift. The results obtained contribute to our understanding of immune pathology in chronic urticaria. |
| تدمد: | 2313-741X 1563-0625 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73357b47c3fed18f8072a8702a57d3cTest https://doi.org/10.15789/1563-0625-2015-1-39-46Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f73357b47c3fed18f8072a8702a57d3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2313741X 15630625 |
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