التفاصيل البيبلوغرافية
| العنوان: |
Association Between HLA-A*32:01 and Vancomycin-Induced DRESS Syndrome in Two Pediatric Cases Using Multiple Antibiotics. |
| المؤلفون: |
KOKEN, Gizem, ERTOY KARAGÜL, Hacer Ilbilge, POLAT TERECE, Sinem, DOGAN KUZUCA, Tutku, TEKER DUZTAS, Demet, EGRITAS GURKAN, Odul, DENIZ, Melis, AKTAS TAPISIZ, Anil, OZMEN, Mehmet Cuneyt, GONEN, Sevim, SOYLEMEZOGLU, Oguz, BAKIRTAS, Arzu |
| المصدر: |
Asthma Allergy Immunology / Astim Allerji Immunoloji; Apr2024, Vol. 22 Issue 1, p85-88, 4p |
| مصطلحات موضوعية: |
STEROID drugs, ANTIBIOTICS, DRUG allergy, DRESS syndrome, DISCHARGE planning, VANCOMYCIN, METHYLPREDNISOLONE, HLA-B27 antigen, SKIN tests, HAPLOTYPES, ALLELES, MEROPENEM |
| مصطلحات جغرافية: |
MIDDLE East |
| مستخلص: |
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but life-threatening drug hypersensitivity reaction. It has recently been shown that those carrying some human leukocyte antigen (HLA) haplotypes are at high risk for the development of DRESS syndrome with some drugs. There is a strong association with HLA-A*32:01 positivity and vancomycin-induced DRESS syndrome. Here, we present two pediatric cases, one Turkish and the other Syrian, both of whom developed DRESS syndrome during the use of multiple antibiotics included vancomycin, and were shown to have HLA-A*32:01 positivity. To determine the causative drug in patients with DRESS syndrome, patch testing can be administered at least six months after the reaction while the lymphocyte transformation test can only be performed in reference centers. Therefore, delays may occur in identifying the causative drug, especially in patients using multiple drugs. As in our patients, it is important to note that screening for HLA-A*32:01 may enable earlier detection of the responsible drug, which is vancomycin. [ABSTRACT FROM AUTHOR] |
|
Copyright of Asthma Allergy Immunology / Astim Allerji Immunoloji is the property of Turkish National Society of Allergy & Clinical Immunology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
