المؤلفون: J. Graessler, Ulf Smith, Marie-France Hivert, Antigone S. Dimas, Joshua W. Knowles, Stéphane Cauchi, Karen L. Mohlke, Michael Boehnke, David Meyre, Nicholas J. Wareham, Ci Song, Denis Rybin, Erik Ingelsson, Mario A. Morken, Anne U. Jackson, Michael R. Erdos, Peter Kovacs, Fahim Abbasi, Claudia Langenberg, Ke Hao, Andreas Pfeiffer, Thomas Quertemous, Lars Lind, Stefan R. Bornstein, Suzannah Bumpstead, Alena Stančáková, Lori L. Bonnycastle, Michael Stumvoll, Oluf Pedersen, Themistocles L. Assimes, Inês Barroso, Andrea Benazzo, Richard M. Watanabe, Magic Investigators, Josée Dupuis, Inga Prokopenko, Heather M. Stringham, Felicity Payne, Markku Laakso, Antje Fischer-Rosinsky, Francis S. Collins, Mark Walker, James B. Meigs, Torben Hansen, Peter Schwarz, Xia Yang, Yvonne Böttcher, Hans-Ulrich Häring, Anke Tönjes, Narisu Narisu, Cécile Lecoeur, Jaakko Tuomilehto, Reedik Mägi, Joachim Spranger, Amy J. Swift, Johanna Kuusisto, Jose C. Florez, Niels Grarup, Philippe Froguel, Vasiliki Lagou, Peter S. Chines, Mark I. McCarthy, Adam Barker, Trine Welløv Boesgaard, Richard N. Bergman

المصدر: Diabetes 63, 2158-2171 (2013)
Diabetes
Diabetes, vol 63, iss 6
Dimas, A S, Lagou, V, Barker, A, Knowles, J W, Magi, R, Hivert, M F, Benazzo, A, Rybin, D, Jackson, A U, Stringham, H M, Song, C, Fischer-Rosinsky, A, Boesgaard, T W, Grarup, N, Abbasi, F A, Assimes, T L, Hao, K, Yang, X, Lecoeur, C, Barroso, I, Bonnycastle, L L, Bottcher, Y, Bumpstead, S, Chines, P S, Erdos, M R, Graessler, J, Kovacs, P, Morken, M A, Narisu, N, Payne, F, Stancakova, A, Swift, A J, Tonjes, A, Bornstein, S R, Cauchi, S, Froguel, P, Meyre, D, Schwarz, P E H, Haring, H U, Smith, U, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, Quertemous, T, Lind, L, Hansen, T, Pedersen, O, Walker, M, Pfeiffer, A F H, Spranger, J, Stumvoll, M, Meigs, J B, Wareham, N J, Kuusisto, J, Laakso, M, Langenberg, C, Dupuis, J, Watanabe, R M, Florez, J C, Ingelsson, E, McCarthy, M I, Prokopenko, I & Investigators, M 2014, ' Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity ', Diabetes, vol. 63, no. 6, pp. 2158-2171 . https://doi.org/10.2337/db13-0949Test

مصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, Insulin Resistance/genetics, Type 2 diabetes, Medical and Health Sciences, Endocrinology, 0302 clinical medicine, Gene Frequency, Risk Factors, Insulin-Secreting Cells, Insulin Secretion, 2.1 Biological and endogenous factors, Cluster Analysis, Insulin, Aetiology, 2. Zero hunger, Genetics, 0303 health sciences, SLC30A8, Medicine (all), Diabetes, Single Nucleotide, Diabetes and Metabolism, Diabetes Mellitus, Type 2/genetics, Female, Type 2, Insulin processing, medicine.medical_specialty, Insulin/metabolism, Quantitative Trait Loci, Socio-culturale, 030209 endocrinology & metabolism, Biology, Autoimmune Disease, Polymorphism, Single Nucleotide, MAGIC Investigators, Endocrinology & Metabolism, 03 medical and health sciences, Insulin-Secreting Cells/metabolism, Insulin resistance, Clinical Research, Alleles, Diabetes Mellitus, Type 2, Genetic Variation, Genome-Wide Association Study, Humans, Insulin Resistance, Transcription Factors, Genetic Predisposition to Disease, Internal Medicine, Diabetes mellitus, Internal medicine, Genetic model, Diabetes Mellitus, medicine, Transcription Factors/metabolism, Polymorphism, Metabolic and endocrine, 030304 developmental biology, Glycemic, Prevention, medicine.disease, biology.protein, Quantitative Trait Loci/genetics, TCF7L2

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec76408386665bb3ac65c80f7efd345Test
https://doi.org/10.2337/db13-0949Test

المؤلفون: Michael Boehnke, Luigi Ferrucci, Aarti Surti, Jaakko Tuomilehto, Karen L. Mohlke, Candace Guiducci, Lee M. Kaplan, Rory Collins, Leena Peltonen, Qiong Yang, Cristen J. Willer, Francis S. Collins, Angelo Scuteri, Christopher J. O'Donnell, Edward G. Lakatta, Serkalem Demissie, Johanna Kuusisto, John C. Chambers, Amy J. Swift, Leif Groop, Markku Laakso, Gina M. Peloso, Sekar Kathiresan, Jouko Sundvall, G. Mark Lathrop, Gonçalo R. Abecasis, Benjamin F. Voight, Jose M. Ordovas, Veikko Salomaa, Eric E. Schadt, Robert Clarke, David Altshuler, David Schlessinger, Diana Zelenika, Pilar Galan, Serge Hercberg, Derrick A Bennett, Kari Kubalanza, Laura J. Scott, Kiran Musunuru, Kathryn L. Lunetta, Serena Sanna, Marju Orho-Melander, L. Adrienne Cupples, Toshiko Tanaka, Gabriel Crawford, Pierre Meneton, Josée Dupuis, Anne U. Jackson, Sarah Parish, Paul I.W. de Bakker, Yun Li, Olle Melander, Mario A. Morken, Manuela Uda, Heather M. Stringham, Lori L. Bonnycastle, Noël P. Burtt, Paul Scheet, Richard N. Bergman, Jaspal S. Kooner

مصطلحات موضوعية: Adult, Male, Multifactorial Inheritance, medicine.medical_specialty, Quantitative Trait Loci, Blood lipids, Genome-wide association study, 030204 cardiovascular system & hematology, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, chemistry.chemical_compound, Delta-5 Fatty Acid Desaturase, 0302 clinical medicine, Meta-Analysis as Topic, ANGPTL4, Internal medicine, Genetics, medicine, Humans, RNA, Messenger, Allele, Alleles, Triglycerides, Dyslipidemias, 030304 developmental biology, 0303 health sciences, Triglyceride, Cholesterol, Cholesterol, HDL, Reproducibility of Results, Cholesterol, LDL, Syndrome, Middle Aged, medicine.disease, 3. Good health, Phenotype, Endocrinology, Gene Expression Regulation, Liver, chemistry, Female, lipids (amino acids, peptides, and proteins), Dyslipidemia, Genome-Wide Association Study, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d725a804494fa65d0b3eab2f377b0f76Test
https://ora.ox.ac.uk/objects/uuid:4bf7b381-5e10-41d4-99a6-b6501ceded24Test

المؤلفون: Kenneth Rice, Amy J. Swift, Veronique Vitart, Lu Qi, Kaisa Silander, Olivier Le Bacquer, Laura Crisponi, David S. Siscovick, Bo Isomaa, Anne U. Jackson, Anke Tönjes, Richard N. Bergman, Rosa Maria Roccasecca, Luigi Ferrucci, Narisu Narisu, Kari Stefansson, Holly E. Syddall, Giuseppe Paolisso, Kim L. Ward, Paul Elliott, Scott M. Grundy, Paul Johnson, Jerome I. Rotter, Philippe Froguel, James B. Meigs, George Davey Smith, Andrew T. Hattersley, Leena Peltonen, Eric J.G. Sijbrands, Serena Sanna, María TeresaMartínez-Larrad, David Altshuler, Harald Grallert, Caroline S. Fox, Nita G. Forouhi, Dorret I. Boomsma, Harry Campbell, Jean Tichet, Angelo Scuteri, Aroon D. Hingorani, Daniel S. Pearson, Meena Kumari, Silvia Naitza, Shah Ebrahim, Manjinder S. Sandhu, Jose C. Florez, Cyrus Cooper, David M. Nathan, Joseph Hung, Fredrik Karpe, Ozren Polasek, Philip J. Barter, Ruth McPherson, Benjamin F. Voight, Wolfgang Rathmann, Abbas Dehghan, Udo Seedorf, Beverley M. Shields, Antti Jula, Pau Navarro, Josephine M. Egan, Rune R. Frants, Leif Groop, Gunnar Sigursson, Seppo Koskinen, Vincent Mooser, François Pattou, Jing Hua Zhao, Irene Pichler, John F. Peden, Göran Hallmans, Toshiko Tanaka, Ruth J. F. Loos, Peter Kovacs, Andrew D. Morris, Cécile Lecoeur, Jeffrey R. O'Connell, Massimo Mangino, Nicole Vogelzangs, Rhian Gwilliam, Gordon H. Williams, Carina Zabena, Naomi Hammond, Amélie Bonnefond, Björn Zethelius, Joachim Spranger, Nancy L. Pedersen, Christopher J. Groves, Nicholas J. Timpson, George Dedoussis, Veikko Salomaa, Peter Henneman, Andrew Walley, Serge Hercberg, Ian N. M. Day, Simon Heath, Matt Neville, Alex S. F. Doney, Robert Clarke, Olov Rolandsson, Panos Deloukas, Eric Boerwinkle, Y. AnteroKesaniemi, Mike Sampson, Gerard Waeber, Sven Bergmann, Ben A. Oostra, Manuel Serrano-Ríos, Mandy van Hoek, Christine Cavalcanti-Proença, Anna L. Gloyn, Ulla Sovio, Andrew P. Morris, Anneli Pouta, Amanda J. Bennett, Paul Scheet, Peter Schwarz, Jaakko Tuomilehto, Hugh Watkins, Johanna Kuusisto, Denis Rybin, Anna LiisaHartikainen, Maria GraziaFranzosi, Unnur Thorsteinsdottir, Rafn Benediktsson, Alan F. Wright, Colin N. Apalmer, Anuj Goel, Yavuz Ariyurek, Lars Lind, Robert Sladek, Stefan R. Bornstein, Reedik Mägi, Laila Simpson, Tim D. Spector, Paul W. Franks, Nicholas L. Smith, John R. B. Perry, Peter Vollenweider, Suzannah Bumpstead, Ruth E. Pakyz, Christa Meisinger, Alan R. Shuldiner, Josée Dupuis, Man Li, Eric J. Brunner, Francis S. Collins, Torben Hansen, James F. Wilson, Guangju Zhai, Igor Rudan, Nicole L. Glazer, Marco Orrù, Pierre Meneton, Knut Borch-Johnsen, Eleanor Wheeler, Gonçalo R. Abecasis, Mark I. McCarthy, Jouke JanHottenga, Inga Prokopenko, Ping An, Jérôme Delplanque, Albert Hofman, Andrew B. Singleton, Gabe Crawford, Thomas A. Buchanan, Avan Aihie Sayer, Richard M. Watanabe, David Schlessinger, A C Fedson, André G. Uitterlinden, Frank B. Hu, Jaqueline C. MWitteman, Dhiraj Varma, Ingrid B. Borecki, Sutapa Mukherjee, Murielle Bochud, Barbara Thorand, Christian Gieger, Lori L. Bonnycastle, Stephen J. Sharp, Markus Perola, Caroline Hayward, Kristin Ardlie, J. Graessler, Robert W. Mahley, Toby Johnson, Jian'an Luan, Joshua C. Randall, Cornelia M. van Duijn, Samuli Ripatti, Ko Willems van Dijk, Valgerdur Steinthorsdottir, Yurii S. Aulchenko, G. Mark Lathrop, Christian Dina, Eleftheria Zeggini, Cecilia M. Lindgren, Stavroula Kanoni, Timothy M. Frayling, Dawn M. Waterworth, Marika Kaakinen, Timo T. Valle, Diana Zelenika, Yii Der IdaChen, Angela Silveira, Nigel W. Rayner, Aimo Ruokonen, Yun Li, Cristian Pattaro, Annelli Sandbæk, Richa Saxena, Danielle Posthuma, Steven A. McCarroll, Niels Grarup, Samy Hadjadj, Pilar Galan, Xijing Han, Lyle J. Palmer, Ulf Gyllensten, Peter P. Pramstaller, Manuela Uda, Jarred B. McAteer, Brenda W.J.H. Penninx, Debbie A Lawlor, Torben Jørgensen, Beatrice Knight, Yvonne Böttcher, Claudia Langenberg, Nicole Soranzo, Ghislain Rocheleau, Erik Ingelsson, Mario A. Morken, Michael Roden, Felicity Payne, David R. Hillman, Michael Marmot, Karen L. Mohlke, Heather M. Stringham, Bruce M. Psaty, Gudmar Thorleifsson, Yoav Ben-Shlomo, Inês Barroso, W. H. Linda Kao, James S. Pankow, Valeriya Lyssenko, Nicholas J. Wareham, Tiinamaija Tuomi, Ann ChristineSyvänen, Braxton D. Mitchell, Alisa K. Manning, Mika Kivimäki, Peter Wagner, Praveen Sethupathy, G. BragiWalters, Jaakko Kaprio, Kijoung Song, Marjo Riitta-Järvelin, Michael A. Province, Andrew A. Hicks, Marilyn C. Cornelis, Sarah H. Wild, David Meyre, Guillaume Charpentier, Patrik K. E. Magnusson, David Melzer, Jennie Hui, Peter Shrader, Michael Stumvoll, Mark O. Goodarzi, Michael R. Erdos, Oluf Pedersen, Andreas Pfeiffer, Augustine Kong, Christian Herder, Laura J. Scott, John W. GYarnell, Kirsten Ohm Kyvik, Beverley Balkau, Antje Fischer-Rosinsky, Gonneke Willemsen, Thomas Illig, Neelam Hassanali, Markku Laakso, Michael Boehnke, John Beilby, Christopher S. Franklin, Fernando Rivadeneira, M. Carola Zillikens, Michael N. Weedon, Antonio Cao, Mark E. Cooper, Simon C. Potter, Eco J. C. de Geus, H.-Erich Wichmann, Amanda F. Elliott, Lachlan J. McOin, Sophie Visvikis-Siest, Thomas Sparsø, Laura J. McCulloch, Taina K. Lajunen, Peter S. Chines, Nabila Bouatia-Naji

المساهمون: Medical Research Council (MRC), Biological Psychology, Functional Genomics, Neuroscience Campus Amsterdam - Anxiety & Depression, Neuroscience Campus Amsterdam - Attention & Cognition, EMGO+ - Mental Health, Ophthalmology, Epidemiology, Clinical Genetics, Dermatology, Internal Medicine, DIAGRAM Consortium, GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, MAGIC investigators, Human genetics, Psychiatry, EMGO - Mental health, NCA - Attention & Cognition, NCA - Anxiety & Depression

المصدر: Nature Genetics
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Hottenga, J J, de Geus, E J C, Kaprio, J, Kyvik, K O, Pedersen, N L, Perola, M, Posthuma, D, Rivadeneira, F, Uitterlinden, A G, Willems van Dijk, K, van Hoek, M, Vogelzangs, N, Willemsen, G, Witteman, J C M, Zillikens, M C, Penninx, B W J H, Boomsma, D I, van Duijn, C M, Aulchenko, Y S, Waterworth, D, Vollenweider, P, Peltonen, L, Mooser, V, Abecasis, G R, Wareham, N J, Sladek, R, Froguel, P, Watanabe, R M, Meigs, J B, Groop, L C, Boehnke, M, McCarthy, M I, Florez, J C & Barroso, I 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520Test
Nature genetics
U32
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Qi, L, Timpson, N J, Hayward, C, Vitart, V, Wild, S H, Morris, A, Rudan, I, Wright, A F & Campbell, H & Wilson, J F 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520Test
Nature Genetics, 42(2), 105-116. Nature Publishing Group
Yarnell, J 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ' Nature Genetics, vol. 42, no. 2, pp. 105-119 . DOI: 10.1038/ng.520
Nature Genetics; Vol 42
Nature Genetics, 42(2), 105-U32. Nature Publishing Group
Nature genetics, vol. 42, no. 2, pp. 105-116
Nature Genetics, 42(5), 464-464
Nature Genetics, 42(2), 105
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T H, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Lu, Q, Timpson, N J, Gieger, C, Zabena, C, Rocheleau, G, Ingelsson, E, An, P, O'Connell, J, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-16 . https://doi.org/10.1038/ng.520Test

مصطلحات موضوعية: Blood Glucose, Netherlands Twin Register (NTR), Candidate gene, Genome-wide association study, Type 2 diabetes, CIRCADIAN CLOCK, TRIGLYCERIDE LEVELS, 0302 clinical medicine, Delta-5 Fatty Acid Desaturase, Databases, Genetic, Homeostasis, GENETICS & HEREDITY, Anders Hamsten on behalf of Procardis Consortium, Child, Genetics, PLASMA-GLUCOSE, 0303 health sciences, Glucokinase regulatory protein, COMMON VARIANTS, 11 Medical And Health Sciences, Fasting, MAGIC investigators, 3. Good health, MODEL ASSESSMENT, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, ESSENTIAL COMPONENTS, Adolescent, DNA Copy Number Variations, Alleles, Blood Glucose/genetics, Blood Glucose/metabolism, DNA Copy Number Variations/genetics, Diabetes Mellitus, Type 2/genetics, Fasting/blood, Gene Expression Regulation, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Homeostasis/genetics, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide/genetics, Quantitative Trait Loci/genetics, Quantitative Trait, Heritable, Reproducibility of Results, Quantitative Trait Loci, 030209 endocrinology & metabolism, Biology, DIAGRAM Consortium, INSULIN-SECRETION, Polymorphism, Single Nucleotide, Article, Fasting glucose, 03 medical and health sciences, Insulin resistance, SDG 3 - Good Health and Well-being, Diabetes mellitus, Internal medicine, genome wide association study, glucose, diabetes type 2, medicine, GIANT Consortium, Allele, GENOME-WIDE ASSOCIATION, Global BPgen Consortium, 030304 developmental biology, Glycemic, Science & Technology, genome-wide association beta-cell dysfunction plasma-glucose insulin-secretion triglyceride levels essential components model assessment common variants circadian clock disease risk, DISEASE RISK, 06 Biological Sciences, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Genetic Loci, biology.protein, BETA-CELL DYSFUNCTION, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31914cd113c85ee43e2a501595f313aTest

المؤلفون: Ryan M. McDaniell, Huntington F. Willard, Katerina S. Kucera, Francis S. Collins, Gregory E. Crawford, Terrence S. Furey, Lingyun Song, Alan P. Boyle, Jason D. Lieb, Vishwanath R. Iyer, Damian Keefe, Anna Battenhouse, Mario A. Morken, Ewan Birney, Zheng Liu, Michael R. Erdos, Laura J. Scott, Bum Kyu Lee

المصدر: Science

مصطلحات موضوعية: Male, CCCTC-Binding Factor, Chromatin Immunoprecipitation, Black People, Biology, Polymorphism, Single Nucleotide, White People, Article, Cell Line, Nuclear Family, X Chromosome Inactivation, Genetic variation, Chromosomes, Human, Deoxyribonuclease I, Humans, Regulatory Elements, Transcriptional, Allele, Transcription factor, Alleles, Genetics, Chromosomes, Human, X, Multidisciplinary, Binding Sites, Chromosome, Genetic Variation, Sequence Analysis, DNA, Phenotype, Chromatin, Repressor Proteins, Gene Expression Regulation, Human genome, Female, Chromatin immunoprecipitation, Protein Binding, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5953ae718fdd2cb686dd0ac6f954b0Test
https://pubmed.ncbi.nlm.nih.gov/20299549Test

المؤلفون: Elaine M. Dennison, Claes Ladenvall, J. Graessler, Timo T. Valle, Anke Tönjes, Narisu Narisu, Heather M. Stringham, Laura J. Scott, Björn Zethelius, Jose C. Florez, Erik Ingelsson, Mario A. Morken, Felicity Payne, Michael R. Erdos, David M. Nathan, Leif Groop, James B. Meigs, Marie-France Hivert, Karen L. Mohlke, Themistocles L. Assimes, Peter Kovacs, Inês Barroso, Josée Dupuis, Francis S. Collins, Laura Pascoe, Gordon H. Williams, Mark I. McCarthy, Richard N. Bergman, Caroline S. Fox, Mark Walker, Thomas A. Buchanan, Avan Aihie Sayer, Bo Isomaa, Inga Prokopenko, John R. Petrie, Ann-Christine Syvänen, Anne U. Jackson, Antje Bergmann, Amy J. Swift, Johanna Kuusisto, Yvonne Böttcher, Karen A. Jameson, Valeriya Lyssenko, Lars Lind, Stefan R. Bornstein, Fahim Abbasi, Suzannah Bumpstead, Nicholas J. Wareham, Ele Ferrannini, Tiinamaija Tuomi, Christian Berne, Richard M. Watanabe, Lori L. Bonnycastle, Stephen J. Sharp, Peter Schwarz, Claudia Langenberg, Ke Hao, Peter S. Chines, Cyrus Cooper, Jaakko Tuomilehto, Reedik Mägi, Markku Laakso, Peter Shrader, Michael Stumvoll, Joshua W. Knowles, Michael Boehnke, Thomas Quertermous

المصدر: Diabetes
Diabetes; Vol 59

مصطلحات موضوعية: Fatty Acid Desaturases, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Genome-wide association study, Type 2 diabetes, Biology, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Germinal Center Kinases, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, 0302 clinical medicine, Delta-5 Fatty Acid Desaturase, Meta-Analysis as Topic, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Hyperinsulinemia, Genetics, Glucose homeostasis, Humans, Insulin, Alleles, 030304 developmental biology, Proinsulin, Homeodomain Proteins, 0303 health sciences, Tumor Suppressor Proteins, medicine.disease, Endocrinology, Glucose, Genetic Loci, Original Article, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein, Insulin processing, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af87462d5894956d361ce51074dfab91Test
https://pubmed.ncbi.nlm.nih.gov/20185807Test

المؤلفون: Karol Estrada, Thomas Meitinger, Christopher J. Groves, Tim D. Spector, Paul W. Franks, Weihua Zhang, Nicholas J. Timpson, Leena Peltonen, M. Carola Zillikens, Alexander W. Drong, Leonie C. Jacobs, Massimo Mangino, Nita G. Forouhi, Fredrik Karpe, Inga Prokopenko, Amanda J. Bennett, G. Mark Lathrop, Cornelia M. van Duijn, Albert Hofman, Michael Boehnke, Inês Barroso, Veikko Salomaa, Lu Qi, John F. Peden, Fernando Rivadeneira, Mark I. McCarthy, Jaakko Tuomilehto, Joel N. Hirschhorn, Nilesh J. Samani, Frank B. Hu, Edward G. Lakatta, Alex S. F. Doney, Najaf Amin, Anders Hamsten, Hugh Watkins, Johanna Kuusisto, Elizabeth K. Speliotes, Narisu Narisu, Guido Fischer, Wendy L. McArdle, David Hadley, Manjinder S. Sandhu, Francis S. Collins, Paul Elliott, Vincent Mooser, Luigi Ferrucci, Leif Groop, H.-Erich Wichmann, Serena Sanna, Xin Yuan, Anna F. Dominiczak, Peter S. Chines, Lachlan J. M. Coin, Lynn Cherkas, Cyrus Cooper, Mario A. Morken, Colin N. A. Palmer, Frida Renström, Blanca M. Herrera, Kijoung Song, Markku Laakso, Marjo-Riitta Järvelin, Kaisa Silander, David Schlessinger, Kari Stefansson, Peter Nordström, David P. Strachan, Angelo Scuteri, Michael N. Weedon, Jia N.an Luan, Rolf Holle, Joshua C. Randall, Yurii S. Aulchenko, Aimo Ruokonen, Stefania Bandinelli, Andrew D. Morris, Shah Ebrahim, Noha Lim, Nicholas J. Wareham, Tiinamaija Tuomi, Mark J. Caulfield, Paul Scheet, Karen L. Mohlke, Gudmar Thorleifsson, Debbie A Lawlor, Karen A. Jameson, Peter Almgren, Lori L. Bonnycastle, Candace Guiducci, Timothy M. Frayling, David J. Hunter, Amy J. Swift, Peter Vollenweider, Iris M. Heid, Stephen J. Chanock, Felicity Payne, Ruth J. F. Loos, George Davey Smith, Gonçalo R. Abecasis, Jaana Laitinen, Andrew T. Hattersley, Cristen J. Willer, Suzannah Bumpstead, G. Bragi Walters, Pekka Jousilahti, Harald Grallert, Laura J. Scott, Panos Deloukas, Cuilin Zhang, Ben A. Oostra, Thomas Illig, Claudia Lamina, Dawn M. Waterworth, Angela Doering, Patricia B. Munroe, Toshiko Tanaka, Chris Wallace, Unnur Thorsteinsdottir, Gabriel Crawford, John C. Chambers, John W. Holloway, Christian Gieger, Gérard Waeber, Jacqueline C.M. Witteman, Ian N. M. Day, Michael R. Erdos, Augustine Kong, Bo Isomaa, Anne U. Jackson, Scott M. Grundy, Andrew P. Morris, Hua Zhao Jing, Aki S. Havulinna, André G. Uitterlinden, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Richard N. Bergman, Anna Nordström, Manuela Uda, Jaspal S. Kooner, Nicole Soranzo, Heather M. Stringham, Helen N. Lyon

المساهمون: Broad Institute of MIT and Harvard, Peltonen, Leena, Hunter, David J., Guiducci, Candace, Crawford, Gabriel, Hirschhorn, Joel N., Lyon, Helen N., Speliotes, Elizabeth K., Medical Research Council (MRC)

المصدر: PLoS genetics
PLoS Genet. 5:e1000508 (2009)
PLoS Genetics, vol. 5, no. 6, pp. e1000508
PLoS
PLoS Genetics
PLoS Genetics; Vol 5
Lindgren, C M, Heid, I M, Randall, J C, Lamina, C, Steinthorsdottir, V, Qi, L, Speliotes, E K, Thorleifsson, G, Willer, C J, Herrera, B M, Jackson, A U, Lim, N, Scheet, P, Soranzo, N, Amin, N, Aulchenko, Y S, Chambers, J C, Drong, A, Luan, J, Lyon, H N, Rivadeneira, F, Sanna, S, Timpson, N J, Zillikens, M C, Jing, H Z, Almgren, P, Bandinelli, S, Bennett, A J, Bergman, R N, Bonnycastle, L L, Bumpstead, S J, Chanock, S J, Cherkas, L, Chines, P, Coin, L, Cooper, C, Crawford, G, Doering, A, Dominiczak, A, Doney, A S F, Ebrahim, S, Elliott, P, Erdos, M R, Estrada, K, Ferrucci, L, Fischer, G, Forouhi, N G, Gieger, C, Grallert, H, Groves, C J, Grundy, S, Guiducci, C, Hadley, D, Hamsten, A, Havulinna, A S, Hofman, A, Holle, R, Holloway, J W, Illig, T, Isomaa, B, Jacobs, L C, Jameson, K, Jousilahti, P, Karpe, F, Kuusisto, J, Laitinen, J, Lathrop, G M, Lawlor, D A, Mangino, M, McArdle, W L, Meitinger, T, Morken, M A, Morris, A P, Munroe, P, Narisu, N, Nordström, A, Nordström, P, Oostra, B A, Palmer, C N A, Payne, F, Peden, J F, Prokopenko, I, Renström, F, Ruokonen, A, Salomaa, V, Sandhu, M S, Scott, L J, Scuteri, A, Silander, K, Song, K, Yuan, X, Stringham, H M, Swift, A J, Tuomi, T, Uda, M, Vollenweider, P, Waeber, G, Wallace, C, Walters, G B, Weedon, M N, Witteman, J C M, Zhang, C, Zhang, W, Caulfield, M J, Collins, F S, Smith, G D, Day, I N M, Franks, P W, Hattersley, A T, Hu, F B, Jarvelin, M R, Kong, A, Kooner, J S, Laakso, M, Lakatta, E, Mooser, V, Morris, A D, Peltonen, L, Samani, N J, Spector, T D, Strachan, D P, Tanaka, T, Tuomilehto, J, Uitterlinden, A G, Van Duijn, C M, Wareham, N J, Watkins, H, Waterworth, D M, Boehnke, M, Deloukas, P, Groop, L, Hunter, D J, Thorsteinsdottir, U, Schlessinger, D, Wichmann, H E, Frayling, T M, Abecasis, G R, Hirschhorn, J N, Loos, R J F, Stefansson, K, Mohlke, K L, Barroso, I & McCarthy, M I 2009, ' Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution ', PLoS Genetics, vol. 5, no. 6, e1000508 . https://doi.org/10.1371/journal.pgen.1000508Test
PLoS Genetics, Vol 5, Iss 6, p e1000508 (2009)

مصطلحات موضوعية: Male, Cancer Research, Genome-wide association study, Giant Consortium, QH426-470, FTO gene, Body Mass Index, Cohort Studies, Diabetes and Endocrinology/Obesity, 0302 clinical medicine, Waist–hip ratio, Germany, Body Fat Distribution, Environmental conditions, Age of Onset, Procardis Consortia, Child, Genetics and Genomics/Genetics of Disease, Genetics (clinical), Adiposity, Genetics & Heredity, Genetics and Genomics/Medical Genetics, Genetics, 0303 health sciences, 3. Good health, Diabetes and Endocrinology, Wellcome Trust Case Control Consortium, Female, France, Waist Circumference, Lysophospholipase, Oxidoreductases, Life Sciences & Biomedicine, Research Article, Adult, Waist, Adolescent, Single-nucleotide polymorphism, Genetics and Genomics/Complex Traits, Biology, Polymorphism, Single Nucleotide, Sequence variants, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, Humans, Genetic Predisposition to Disease, Obesity, Diabetes and Endocrinology/Type 2 Diabetes, Molecular Biology, Alleles, Ecology, Evolution, Behavior and Systematics, Imputation, 030304 developmental biology, Genetic association, waist circumference, adult obesity, fto gene, environmental-conditions, insulin-resistance, sequence variants, common variants, expression, imputation, height, 0604 Genetics, Science & Technology, Height, Genome, Human, Waist-Hip Ratio, Common variants, Body Weight, Genetics and Genomics, Insulin-resistance, medicine.disease, Transcription Factor AP-2, Genetic Loci, Methionine Sulfoxide Reductases, Adult obesity, Body mass index, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study

وصف الملف: application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e30b4d7a2cfa667fce91f99d024b30Test
https://openaccess.sgul.ac.uk/id/eprint/1561/1/pgen.1000508.pdfTest

المؤلفون: Richard N. Bergman, Derrick A Bennett, Cristen J. Willer, Richard M. Watanabe, Nicholas J. Timpson, Karen L. Mohlke, Robert Clarke, Francis S. Collins, Laura J. Scott, Antonio Cao, Angelo Scuteri, Alan R. Shuldiner, Antonella Mulas, G. Mark Lathrop, Andrea Maschio, Samer S. Najjar, Diana Zelenika, Serena Sanna, William L. Duren, Michael Boehnke, Jaakko Tuomilehto, Pilar Galan, James B. Strait, Heather M. Stringham, Debbie A Lawlor, Rory Collins, Ramaiah Nagaraja, Anne U. Jackson, Yun Li, Jouko Sundvall, Sarah Parish, Manuela Uda, George Davey-Smith, Giuseppe Albai, Paul Scheet, Shah Ebrahim, Haiqing Shen, David Schlessinger, Pierre Meneton, Lori L. Bonnycastle, Simon Heath, Gonçalo R. Abecasis, Mario A. Morken, Wei-Min Chen, Edward G. Lakatta, Amy J. Swift, Yoav Ben-Shlomo, Narisu Narisu, Fabio Busonero, Serge Hercberg

المصدر: Nature genetics. 40(2)

مصطلحات موضوعية: medicine.medical_specialty, Apolipoprotein B, Coronary Artery Disease, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Article, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Gene Frequency, Risk Factors, Internal medicine, Genetics, medicine, Humans, Computer Simulation, Allele frequency, Alleles, Triglycerides, 030304 developmental biology, Probability, 0303 health sciences, Likelihood Functions, biology, Cholesterol, Genome, Human, PCSK9, Haplotype, Cholesterol, HDL, Genetic Variation, Cholesterol, LDL, Lipids, Markov Chains, 3. Good health, Endocrinology, chemistry, Haplotypes, ABCA1, Case-Control Studies, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins), Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feacec0805efc5da67b6e02664564eceTest
https://pubmed.ncbi.nlm.nih.gov/18227868Test