التفاصيل البيبلوغرافية
| العنوان: |
The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m). |
| المؤلفون: |
Kalson, Nicholas S., Thompson, Julian, Davies, Andrew J., Stokes, Suzy, Earl, Mark D., Whitehead, Adam, Tyrrell-Marsh, Ian, Frost, Hannah, Montgomery, Hugh |
| المصدر: |
European Journal of Applied Physiology; Feb2009, Vol. 105 Issue 3, p373-379, 7p, 1 Diagram, 5 Charts, 1 Graph |
| مصطلحات موضوعية: |
ANGIOTENSIN converting enzyme, MOUNTAIN sickness, INFLUENCE of altitude, EFFECT of environment on human beings, ALLELES, MOUNTAINEERS, HEALTH |
| مصطلحات جغرافية: |
KILIMANJARO, Mount (Tanzania), TANZANIA |
| مستخلص: |
The I-allele rather than the D-allele of the human angiotensin converting enzyme (ACE) gene has been associated with high-altitude mountaineering success. We investigated whether the I-allele was associated with summit success, and also with AMS development, in altitude-naïve trekkers. Subjects ascended from 1,860 m to the summit over 4 days (n = 34, 'direct-profile') or 5 days (n = 82, 'slower-profile'). Proportionally more II direct-profile subjects were successful than ID or DD, although the difference was not significant (100% of II subjects, 52% ID and 43% DD, P = 0.09). There was no difference in success amongst subjects on the slower-profile (50% II, 45% ID and 58% DD, P = 0.54). There was a non-significant trend for increasing AMS scores in ID/DD subjects. Amongst tourist trekkers on Mt. Kilimanjaro the I-allele is not associated with summit success. No evidence is found to support an association between ACE genotype and AMS development. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Applied Physiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
