التفاصيل البيبلوغرافية
| العنوان: |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
| المؤلفون: |
Sampaio-Barros, Percival D., Conde, Roseneide A., Donadi, Eduardo A., Kraemer, Maria Helena S., Persoli, Ligia, Coimbra, Ibsen B., Costallat, Lilian Teresa L., Samara, Adil M., Bértolo, Manoel B. |
| المساهمون: |
Universidade Estadual Paulista (UNESP) |
| سنة النشر: |
2003 |
| المجموعة: |
Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: |
Alleles, Followup, HLA-B27, Spondyloarthropathies, Undifferentiated spondyloarthropathies |
| الوصف: |
Objective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
2632-2637 |
| اللغة: |
English |
| تدمد: |
0315-162X |
| العلاقة: |
Journal of Rheumatology; Journal of Rheumatology, v. 30, n. 12, p. 2632-2637, 2003.; http://hdl.handle.net/11449/230960Test; 2-s2.0-0346848790 |
| الإتاحة: |
http://hdl.handle.net/11449/230960Test |
| رقم الانضمام: |
edsbas.51AC8422 |
| قاعدة البيانات: |
BASE |
