The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
| العنوان: | The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study |
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| المؤلفون: | Rudolph E. Tanzi, Dominique Campion, Brit Maren Michaud Schjeide, Diana Zelenika, Lars Lannfelt, Nathalie Fievet, Paola Forti, M. Ilyas Kamboh, Antonio González-Pérez, Hilkka Soininen, Elicer Coto, Steven T. DeKosky, Victoria Alvarez, Carmen Antúnez, Karolien Bettens, Margaret A. Pericak-Vance, Michelangelo Mancuso, Jacques Epelbaum, Kristel Sleegers, Federico Licastro, Giorgio Annoni, Florence Pasquier, Gianfranco Spalletta, Claudine Berr, Florence Richard, Christine Van Broeckhoven, Ana Frank-García, Lars Bertram, Mikko Hiltunen, Daniela Galimberti, Jean-Charles Lambert, Philippe Marambaud, Elisa Porcellini, Maria Del Zompo, Seppo Helisalmi, Nathalie Brouwers, Ignacio Mateo, Corinne Lendon, Gabriele Siciliano, David M. A. Mann, Fernando Valdivieso, Annick Alpérovitch, Jean-François Dartigues, Paola Piccardi, Jesús López-Arrieta, Alberto Pilotto, Mercè Boada, Olivier Hanon, Elio Scarpini, Vilmentas Giedraitis, Didier Hannequin, Benedetta Nacmias, Onofre Combarros, Giovanni Ravaglia, Mark Lathrop, Christophe Tzourio, Paola Bossù, María J. Bullido, Martin Ingelsson, Sandro Sorbi, Paolo Bosco, Philippe Amouyel, Vincenzo Solfrizzi, Sebastiaan Engelborghs, Beatrice Arosio, Francesco Panza, Marc Delepine, Saila Vepsäläinen, Jonathan L. Haines, Peter Paul De Deyn, Gary W. Beecham, Agustín Ruiz, Davide Seripa, Gloria Tognoni, Raffaele Ferri |
| المساهمون: | Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P., Lambert, J, Sleegers, K, González Pérez, A, Ingelsson, M, Beecham, G, Hiltunen, M, Combarros, O, Bullido, M, Brouwers, N, Bettens, K, Berr, C, Pasquier, F, Richard, F, Dekosky, S, Hannequin, D, Haines, J, Tognoni, G, Fiévet, N, Dartigues, J, Tzourio, C, Engelborghs, S, Arosio, B, Coto, E, De Deyn, P, Del Zompo, M, Mateo, I, Boada, M, Antunez, C, Lopez Arrieta, J, Epelbaum, J, Schjeide, B, Frank Garcia, A, Giedraitis, V, Helisalmi, S, Porcellini, E, Pilotto, A, Forti, P, Ferri, R, Delepine, M, Zelenika, D, Lathrop, M, Scarpini, E, Siciliano, G, Solfrizzi, V, Sorbi, S, Spalletta, G, Ravaglia, G, Valdivieso, F, Vepsäläinen, S, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Hanon, O, Piccardi, P, Annoni, G, Mann, D, Marambaud, P, Seripa, D, Galimberti, D, Tanzi, R, Bertram, L, Lendon, C, Lannfelt, L, Licastro, F, Campion, D, Pericak Vance, M, Soininen, H, Van Broeckhoven, C, Alpérovitch, A, Ruiz, A, Kamboh, M, Amouyel, P, Clinical sciences, Neurology |
| المصدر: | Journal of Alzheimer's disease |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Apolipoprotein E, Male, CALHM1, Calcium Channels/genetics, Apolipoprotein E4, Single-nucleotide polymorphism, Biology, Article, polymorphism, Alzheimer Disease/epidemiology, Alzheimer Disease, Genetic variation, Genotype, Humans, Apolipoprotein E4/genetics, Allele, Age of Onset, Polymorphism, Genetic/genetics, Alleles, apolipoprotein E, Aged, Medicine(all), Genetics, Aged, 80 and over, Membrane Glycoproteins, Polymorphism, Genetic, General Neuroscience, Haplotype, Age at onset, General Medicine, Membrane Glycoproteins/genetics, Alzheimer's disease, Middle Aged, Psychiatry and Mental health, Clinical Psychology, Case-Control Studies, Female, Human medicine, Calcium Channels, Geriatrics and Gerontology, Age of onset |
| الوصف: | The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene. |
| وصف الملف: | STAMPA; pdf |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab42b1635b9b0412bd2517fa6c8b060Test https://pubmed.ncbi.nlm.nih.gov/20847397Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ab42b1635b9b0412bd2517fa6c8b060 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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