Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder
| العنوان: | Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder |
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| المؤلفون: | Anne Farmer, Roel A. Ophoff, Peter McGuffin, Lilia I. Abramova, Mads V. Hollegaard, Ole Mors, Omar Gustafsson, Thomas W. Mühleisen, Evangelos Vassos, Srdjan Djurovic, Gulja Babadjanova, Marcella Rietschel, Markus M. Nöthen, Gunnar Morken, Anders D. Børglum, Carmen C. Diaconu, David A. Collier, Lambertus A. Kiemeney, Kari Stefansson, M. Ruggeri, Ingrid Melle, Maria Grigoroiu-Serbanescu, Preben Bo Mortensen, Hreinn Stefansson, István Bitter, Ole A. Andreassen, Stacy Steinberg, Leonard H. van den Berg, Thomas Werge, Barbara Franke, Ruud van Winkel, Dan Rujescu, Vera Golimbet, Gerome Breen, János Réthelyi, Piotr M. Czerski, Joanna Hauser, Sarah Tosato, I. Alex Rubino, Olli Pietiläinen, Erik G. Jönsson, David St Clair, Sven Cichon, Gunter Kenis, Ditte Demontis, Engilbert Sigurdsson, Marc De Hert |
| المساهمون: | Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Amsterdam Neuroscience, Adult Psychiatry |
| المصدر: | Biological Psychiatry, 72(8), 645-650. Elsevier Science Biological psychiatry 72(8), 645-650 (2012). doi:10.1016/j.biopsych.2012.02.040 Biological Psychiatry, 72, 645-50 Biological Psychiatry Biological Psychiatry, 72, 8, pp. 645-50 Biological Psychiatry; Vol 72 Vassos, E, Steinberg, S, Cichon, S, Breen, G, Sigurdsson, E, Andreassen, O A, Djurovic, S, Morken, G, Grigoroiu-Serbanescu, M, Diaconu, C C, Czerski, P M, Hauser, J, Babadjanova, G, Abramova, L I, Mühleisen, T W, Nöthen, M M, Rietschel, M, McGuffin, P, Clair, D S, Gustafsson, O, Melle, I, Pietiläinen, O P H, Ruggeri, M, Tosato, S, Werge, T, Ophoff, R A, Rujescu, D, Børglum, A D, Mors, O, Mortensen, P B, Demontis, D, Hollegaard, M V, van Winkel, R, Kenis, G, De Hert, M, Réthelyi, J M, Bitter, I, Rubino, I A, Golimbet, V, Kiemeney, L A, van den Berg, L H, Franke, B, Jönsson, E G, Farmer, A, Stefansson, H, Stefansson, K, Collier, D A & GROUP Consortium 2012, ' Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder ', Biological Psychiatry, vol. 72, no. 8, pp. 645-650 . https://doi.org/10.1016/j.biopsych.2012.02.040Test Biological psychiatry, 72(8), 645-650. Elsevier USA |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Linkage disequilibrium, Genome-wide association study, Aetiology, screening and detection [ONCOL 5], Linkage Disequilibrium, PBRM1, statistics & numerical data [Databases, Genetic], 0302 clinical medicine, Gene Frequency, genome-wide association, bipolar disorder, PBRM1, SGENE, Databases, Genetic, Odds Ratio, genetics [Schizophrenia], genetics, SGENE, Genetics, bipolar disorder, 0303 health sciences, epidemiology [Europe], Single Nucleotide, Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3], Europe, genetics [European Continental Ancestry Group], Pair 3, genetics [Chromosomes, Human, Pair 3], genetics [Polymorphism, Single Nucleotide], Female, Chromosomes, Human, Pair 3, Human, Genotype, European Continental Ancestry Group, 3p21.1, Locus (genetics), Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, White People, Chromosomes, Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3], 03 medical and health sciences, Databases, Bipolar Disorder, Humans, Genome-Wide Association Study, Schizophrenia, Genetic Predisposition to Disease, Genetic, medicine, ddc:610, Bipolar disorder, Polymorphism, Allele frequency, Settore MED/25 - Psichiatria, Biological Psychiatry, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], 030304 developmental biology, Genetic association, Odds ratio, medicine.disease, schizophrenia, genome-wide association, polybromo 1, genetics [Bipolar Disorder], 030217 neurology & neurosurgery |
| الوصف: | Item does not contain fulltext BACKGROUND: Common genetic polymorphisms at chromosome 3p21.1, including rs2251219 in polybromo 1 (PBRM1), have been implicated in susceptibility to bipolar affective disorder (BP) through genome-wide association studies. Subsequent studies have suggested that this is also a risk locus for other psychiatric phenotypes, including major depression and schizophrenia. METHODS: To replicate the association, we studied 2562 cases with BP and 25,439 control subjects collected from seven cohorts with either genome-wide association or individual genotyping of rs2251219 and tagging single nucleotide polymorphisms across the PBRM1 gene. Results from the different case-control groups were combined with the inverse variance weighting method. RESULTS: In our dataset, rs2251219 was associated with BP (odds ratio [OR] = .89, p = .003), and meta-analysis of previously published data with our nonoverlapping new data confirmed genome-wide significant association (OR = .875, p = 2.68 x 10(-9)). Genotypic data from the SGENE-plus consortium were used to examine the association of the same variant with schizophrenia in an overall sample of 8794 cases and 25,457 control subjects, but this was not statistically significant (OR = .97, p = .21). CONCLUSIONS: There is strong evidence of association of rs2251219 with BP. However, our data do not support association of this marker with schizophrenia. Because the region of association has high linkage disequilibrium, forming a large haplotype block across many genes, it is not clear which gene is causally implicated in the disorder. |
| اللغة: | English |
| تدمد: | 0006-3223 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d15e99571768e434114e1470a2a68bTest https://cris.maastrichtuniversity.nl/en/publications/85b8f1b8-3b89-4bdc-8aa2-6539e0f2766dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02d15e99571768e434114e1470a2a68b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00063223 |
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