التفاصيل البيبلوغرافية
| العنوان: |
Chiral Phosphoric AcidCatalyzed Highly EnantioselectiveFriedel–Crafts Alkylation Reaction of C3-Substituted Indolesto β,γ-Unsaturated α-Ketimino Esters. |
| المؤلفون: |
Bi, Bo1, Lou, Qin-Xin1, Ding, Yu-Yang1, Chen, Sheng-Wei1, Zhang, Sha-Sha1, Hu, Wen-Hui1, Zhao, Jun-Ling1 |
| المصدر: |
Organic Letters. Feb2015, Vol. 17 Issue 3, p540-543. 4p. |
| مصطلحات موضوعية: |
*CHIRALITY, *ENANTIOSELECTIVE catalysis, *PHOSPHORIC acid, *FRIEDEL-Crafts reaction, *ALKYLATION, *SUBSTITUTION reactions, *ESTERS |
| مستخلص: |
A highlyenantioselective C2 Friedel–Crafts alkylation reactionof 3-substituted indoles to β,γ-unsaturated α-ketiminoesters has been developed. This reaction was efficiently catalyzedby a chiral phosphoric acid catalyst. The corresponding C2-substitutedindole derivatives, bearing an α-ketimino ester motif, wereobtained in moderate to high yields (up to 93%) and with high enantioselectivities(up to >99% ee). [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
