التفاصيل البيبلوغرافية
| العنوان: |
The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling. |
| المؤلفون: |
Kukula-Koch, Wirginia, Kruk-Słomka, Marta, Stępnik, Katarzyna, Szalak, Radosław, Biała, Grażyna |
| المصدر: |
International Journal of Molecular Sciences; Dec2017, Vol. 18 Issue 12, p2511, 24p |
| مصطلحات موضوعية: |
BERBERINE, BLOOD-brain barrier, THERAPEUTIC use of plant extracts, THERAPEUTIC use of alkaloids, QSAR models, LABORATORY mice, THERAPEUTICS |
| مستخلص: |
Civilization diseases associated with memory disorders are important health problems occurring due to a prolonged life span. The manuscript shows the results of an in vivo study targeting the emergence of two drug candidates with anti-amnestic properties. The preceding quantitative structure-activity relationship (QSAR) studies provided information on the ability of berberine and magnoflorine to cross the blood-brain barrier (BBB). In the light of these findings, both compounds were purified from crude plant extracts of barberries: berberine--from Berberis siberica using a method published earlier, and magnoflorine--from Berberis cretica by centrifugal partition chromatography (solvent system: ethyl acetate:butanol:water-0.6:1.5:3 v/v/v). Both the compounds were evaluated for their memory enhancing and scopolamine inhibitory properties in an in vivo passive avoidance (PA) test on mice towards short-term and long-term memory. Cognition enhancing properties were observed at the following doses: 5 mg/kg (i.p.) for berberine and 20 mg/kg (i.p.) for magnoflorine. In addition, both the tested isoquinolines with the co-administered scopolamine were found to block long-term but not short-term memory impairment. No influence on the locomotor activity was observed for the tested doses. The results confirmed a marked central activity of magnoflorine and showed the necessity to lower the dosage of berberine. Optimized purification conditions have been elaborated for magnoflorine. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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