Effects of dimethylglycine sodium salt supplementation on growth performance, hepatic antioxidant capacity, and mitochondria-related gene expression in weanling piglets born with low birth weight1
| العنوان: | Effects of dimethylglycine sodium salt supplementation on growth performance, hepatic antioxidant capacity, and mitochondria-related gene expression in weanling piglets born with low birth weight1 |
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| المؤلفون: | Lili Zhang, Chengcheng Feng, Xiaoke Ge, Anan Wang, Kaiwen Bai, Tian Wang, Yongwei Zhao |
| المصدر: | Journal of Animal Science. 96:3791-3803 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Weanling, Biology, Feed conversion ratio, Dimethylglycine, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, Genetics, medicine, Weaning, chemistry.chemical_classification, Glutathione peroxidase, 0402 animal and dairy science, 04 agricultural and veterinary sciences, General Medicine, Malondialdehyde, 040201 dairy & animal science, 030104 developmental biology, Endocrinology, chemistry, Alkaline phosphatase, Animal Science and Zoology, Food Science |
| الوصف: | Dimethylglycine sodium salt (DMG-Na) has exhibited excellent advantages in animal experiments and human health. The present study aimed to investigate the effects of dietary supplementation with 0.1% DMG-Na on the growth performance, hepatic antioxidant capacity, and mRNA expression of mitochondria-related genes in low birth weight (LBW) piglets during weaning period. Sixteen piglets with normal birth weight (NBW) and 16 LBW piglets were fed either a basal diet or a 0.1% DMG-Na supplemented diet from age of 21 to 49 d. Blood and liver samples were collected at the end of the study. The results showed that compared with NBW piglets, LBW piglets exhibited greater (P < 0.05) alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities in the serum. LBW decreased (P < 0.05) the activity of glutathione peroxidase and increased (P < 0.05) the contents of malondialdehyde and H2O2 in liver. DMG-Na supplementation increased (P < 0.05) body weight gain, feed intake, and feed efficiency, decreased (P < 0.05) ALT and AST activities, and reduced the content of H2O2 in LBW piglets. LBW piglets had downregulated (P < 0.05) mRNA expression of thioredoxin 2, thioredoxin reductases 2, and nuclear respiratory factor-1 (Nrf1) in the liver. However, DMG-Na supplementation increased (P < 0.05) mRNA expression of Nrf1 in the liver. In conclusion, DMG-Na supplementation has beneficial effects in alleviating LBW-induced hepatic oxidative damage and changed mitochondrial genes expression levels, which is associated with increased antioxidant enzyme activities and up-regulating mRNA gene abundance. |
| تدمد: | 1525-3163 0021-8812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4f647265218d17527245411b23673116Test https://doi.org/10.1093/jas/sky233Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........4f647265218d17527245411b23673116 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15253163 00218812 |
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