Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke
| العنوان: | Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke |
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| المؤلفون: | Santos, Emilie M. M., Yoo, Albert J., Beenen, Ludo F., Berkhemer, Olvert A., den Blanken, Mark D., Wismans, Carrie, Niessen, Wiro J., Majoie, Charles B., Marquering, Henk A., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Lingsma, Hester F., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, Jan S. P., A A M van Hasselt, Boudewijn, Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., Hertog, Heleen M. Den, Gerrits, Dick G., van den Berg-Vos, Renske M., Sprengers, Marieke E. S., van den Berg, René, Roos, Yvo B. W. E. M. |
| المساهمون: | Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: CARIM - R3.11 - Imaging, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, Other departments, ANS - Neurovascular Disorders, Graduate School, Radiology and Nuclear Medicine, Other Research, ACS - Amsterdam Cardiovascular Sciences, Biomedical Engineering and Physics, Neurology, Radiology & Nuclear Medicine |
| المصدر: | Neuroradiology, 58(2), 133-139. Springer, Cham Neuroradiology, 58, 2, pp. 133-9 Neuroradiology Neuroradiology, 58(2), 133-139. Springer Verlag Neuroradiology, 58(2), 133-139. Springer-Verlag Neuroradiology, 58, 133-9 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Observer (quantum physics), Computed Tomography Angiography, Intraclass correlation, Clinical Neurology, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, X-ray, 03 medical and health sciences, Brain ischemia, Absorptiometry, Photon, 0302 clinical medicine, Thromboembolism, Observer agreements, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Thrombus, Acute ischemic stroke, Computed tomography, Diagnostic Neuroradiology, Aged, Netherlands, Neuroradiology, Observer Variation, Measurement method, business.industry, Reproducibility of Results, Thrombosis, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Cerebral Angiography, Radiographic Image Enhancement, Stroke, Radiology Nuclear Medicine and imaging, Interobserver Variation, Acute Disease, Radiographic Image Interpretation, Computer-Assisted, Female, Neurology (clinical), Intracranial Thrombosis, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Algorithms, 030217 neurology & neurosurgery |
| الوصف: | Introduction Thrombus density may be a predictor for acute ischemic stroke treatment success. However, only limited data on observer variability for thrombus density measurements exist. This study assesses the variability and bias of four common thrombus density measurement methods by expert and non-expert observers. Methods For 132 consecutive patients with acute ischemic stroke, three experts and two trained observers determined thrombus density by placing three standardized regions of interest (ROIs) in the thrombus and corresponding contralateral arterial segment. Subsequently, absolute and relative thrombus densities were determined using either one or three ROIs. Intraclass correlation coefficient (ICC) was determined, and Bland–Altman analysis was performed to evaluate interobserver and intermethod agreement. Accuracy of the trained observer was evaluated with a reference expert observer using the same statistical analysis. Results The highest interobserver agreement was obtained for absolute thrombus measurements using three ROIs (ICCs ranging from 0.54 to 0.91). In general, interobserver agreement was lower for relative measurements, and for using one instead of three ROIs. Interobserver agreement of trained non-experts and experts was similar. Accuracy of the trained observer measurements was comparable to the expert interobserver agreement and was better for absolute measurements and with three ROIs. The agreement between the one ROI and three ROI methods was good. Conclusion Absolute thrombus density measurement has superior interobserver agreement compared to relative density measurement. Interobserver variation is smaller when multiple ROIs are used. Trained non-expert observers can accurately and reproducibly assess absolute thrombus densities using three ROIs. Electronic supplementary material The online version of this article (doi:10.1007/s00234-015-1607-4) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0028-3940 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155812c33ccf89424bee62a0a3f97a23Test https://cris.maastrichtuniversity.nl/en/publications/e123bebd-53d3-452d-b514-f34959454c36Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....155812c33ccf89424bee62a0a3f97a23 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00283940 |
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