Brain mitochondrial alterations after chronic alcohol consumption
| العنوان: | Brain mitochondrial alterations after chronic alcohol consumption |
|---|---|
| المؤلفون: | Carmen García-Ruiz, José C. Fernández-Checa, Inmaculada Almansa, Anna Fernández, María Miranda, Francisco J. Romero, María Muriach, Jorge M. Barcia |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Springer, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Alcohol, Apoptosis, Mitochondrion, Biology, Biochemistry, Mitochondrial Proteins, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, Organelle, medicine, Animals, Atractyloside, chemistry.chemical_classification, Reactive oxygen species, Ethanol, Glutathione Disulfide, Cholesterol, Cytochromes c, Brain, General Medicine, Glutathione, Rats, Mitochondria, Alcoholism, Endocrinology, chemistry, Rat, Apoptosis Regulatory Proteins, Carrier Proteins |
| الوصف: | et al. The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins. This work was supported in part by Funds from Ministerio de Ciencia e Innovación (SAF 2007- 66801), Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I), Ingenio 2010 initiative, RTA (Red de Transtornos Adictivos) and Consolider programms from Instituto de Salud Carlos III, Coopernicus-Santander Programm of the Universidad CEU- Cardenal Herrera, Dirección General de Drogodependencias (Generalitat Valenciana) and FEPAD (Fundación para el Estudio, Prevención y Ayuda a la Drogadicción). |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d906f4d179fda33028d1120667e6506aTest http://hdl.handle.net/10261/35177Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d906f4d179fda33028d1120667e6506a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |