The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population
| العنوان: | The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population |
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| المؤلفون: | Szentkereszty-Kovács, Zita, Fiatal, Szilvia, Szegedi, Andrea, Kovács, Dóra, Janka, Eszter, Herszényi, Krisztina, Holló, Péter, Nikamo, Pernilla, Ståhle, Mona, Remenyik, Éva, Törőcsik, Dániel |
| المصدر: | Archives of Dermatological Research |
| بيانات النشر: | Springer Berlin Heidelberg, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Risk, Original Paper, Hungary, Alcohol Drinking, Population genetics, Alcohol Dehydrogenase, Receptors, Opioid, mu, Middle Aged, Polymorphism, Single Nucleotide, ADH1B gene, OPRM1 gene, Alcoholism, Psoriasis, Humans, Alcohol consumption, Genetic Predisposition to Disease |
| الوصف: | Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (ORadditive = 1.58, 95% CI 1.23–2.03, p |
| اللغة: | English |
| تدمد: | 1432-069X 0340-3696 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::14c4a504110ae61e28cf93e7d253703cTest http://europepmc.org/articles/PMC6594982Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........14c4a504110ae61e28cf93e7d253703c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432069X 03403696 |
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