دورية أكاديمية
Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases
| العنوان: | Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases |
|---|---|
| المؤلفون: | Villalta, D., Mytilinaiou, M. G., Elsner, M., Hentschel, C., Cuccato, J., Somma, V., Schierack, P., Roggenbuck, D., Bogdanos, D. P. |
| المصدر: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84938688047&partnerID=40&md5=25061b87fd51add1e79a72290c9e943bTest. |
| سنة النشر: | 2015 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | AIH, ASGPR, Asialoglycoprotein receptor, Autoantibody, Autoimmune hepatitis, adolescent, adult, aged, Article, autoimmune hepatitis type 1, autoimmune hepatitis type 2, autoimmune liver disease, child, controlled study, cryptogenic liver disease, enzyme linked immunosorbent assay, female, hepatitis C, human, immunofluorescence, major clinical study, male, nonalcoholic fatty liver, prevalence, primary biliary cirrhosis, primary sclerosing cholangitis, priority journal, school child, serology, toxic liver disease |
| الوصف: | Background: The liver asialoglycoprotein receptor (ASGPR) is the only organ-specific autoantigenic target in autoimmune hepatitis (AIH) patients and corresponding autoantibodies (Abs) have been suggested aiding in the serology of autoimmune liver diseases (ALD). Methods: A novel enzyme-linked immunosorbent assay (ELISA) employing purified rabbit ASGPR was used to detect ASGPR Abs in patients with ALD and controls. ASGPR Ab was determined in sera from 172 patients with AIH type 1, AIH type 2 (n = 42), primary biliary cirrhosis (PBC) (n = 113), cryptogenic liver disease (n = 30), toxic liver disease (n = 11), primary sclerosing cholangitis (PSC) (n = 27), HCV infection (n = 25), non-alcoholic steatohepatitis (n = 43) and 100 blood donors. ASGPR Ab positivity was compared with AIH-related Abs (ANA, ASMA, Abs to LKM-1, LC-1, and SLA/LP) in patients with AIH. Results: Patients with AIH-1 and AIH-2 demonstrated an ASGPR Ab prevalence of 29.1% and 16.7%, respectively. ASGPR Ab positivity in patients with AIH-1 and AIH-2 was not significantly different to those in patients with PSC and HCV (p. >. 0.05, respectively). ASGPR Ab levels in all study cohorts were significantly different with the highest medians in patients with AIH, PSC, and HCV infection (p. <. 0.0001). ASGPR Ab can be found as only AIH-specific Ab determined by LIA and ELISA in 24.4% of AIH patients (48/197). Conclusions: The novel ASGPR Ab ELISA is a specific diagnostic tool for ASGPR Ab detection in AIH. In addition to AIH, patients with PSC can demonstrate elevated ASGPR Ab amongst those with ALD suggesting a tolerance break to ASGPR in PSC. © 2015 Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | 98981; http://hdl.handle.net/11615/34484Test |
| DOI: | 10.1016/j.cca.2015.07.021 |
| الإتاحة: | https://doi.org/10.1016/j.cca.2015.07.021Test http://hdl.handle.net/11615/34484Test |
| رقم الانضمام: | edsbas.8167751D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cca.2015.07.021 |
|---|