دورية أكاديمية
Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults:The FIT-AGEING study
| العنوان: | Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults:The FIT-AGEING study |
|---|---|
| المؤلفون: | Vázquez-Lorente, Héctor, Jurado-Fasoli, Lucas, Kohler, Isabelle, Di, Xinyu, Yang, Wei, Osuna-Prieto, Francisco J., Asadov, Sardor, Frias-Rodríguez, José F., Castillo-Garzón, Manuel J., Amaro-Gahete, Francisco J. |
| المصدر: | Vázquez-Lorente , H , Jurado-Fasoli , L , Kohler , I , Di , X , Yang , W , Osuna-Prieto , F J , Asadov , S , Frias-Rodríguez , J F , Castillo-Garzón , M J & Amaro-Gahete , F J 2022 , ' Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults : The FIT-AGEING study ' , Experimental Gerontology , vol. 169 , 111954 , pp. 1-8 . https://doi.org/10.1016/j.exger.2022.111954Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aging, Inflammageing, Lipid mediators, Oxylipins, Vitamin D |
| الوصف: | Introduction: Vitamin D – concretely its active form 1,25-dihydroxyvitamin D (1,25(OH) 2 D) – maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH) 2 D with inflammatory parameters in middle-aged populations – who could be at risk of vitamin D deficiency –. The aim of this study was to investigate the relationship between 1,25(OH) 2 D plasma levels with circulating white blood cells, platelets counts and oxylipins levels. Materials and methods: A total of 74 (53 % women) middle-aged (40–65 years old) adults were recruited for this cross-sectional study. 1,25(OH) 2 D plasma levels were measured using an immunochemiluminometric assay. White blood cells and platelets were analyzed by hemocytometry. ω-6 and ω-3 oxylipins plasma levels were measured using liquid chromatography - tandem mass spectrometry. Simple and multiple linear regression models, and Pearson correlation analyses, were performed to study the association of 1,25(OH) 2 D levels with WBC and platelets counts, and oxylipins, respectively. Results: 1,25(OH) 2 D plasma levels were positively related with linoleic acid-derived oxylipins and isoprostanes plasma levels, whereas an inverse relationship with dihomo-γ-linolenic acid/linoleic acid and arachidonic acid/linoleic acid ratios was unveiled. No significant associations were observed for circulating ω-3 oxylipins, white blood cells levels or platelets count. Conclusions: Linoleic acid-derived oxylipins and isoprostanes plasma levels may be influenced by 1,25(OH) 2 D plasma levels. Further investigations are needed to elucidate the impact of other vitamin D forms upon circulating oxylipins levels. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/0d4c6e0a-6ec5-4734-add7-492fa5f472f4Test |
| DOI: | 10.1016/j.exger.2022.111954 |
| الإتاحة: | https://doi.org/10.1016/j.exger.2022.111954Test https://research.vu.nl/en/publications/0d4c6e0a-6ec5-4734-add7-492fa5f472f4Test https://hdl.handle.net/1871.1/0d4c6e0a-6ec5-4734-add7-492fa5f472f4Test http://www.scopus.com/inward/record.url?scp=85138532556&partnerID=8YFLogxKTest http://www.scopus.com/inward/citedby.url?scp=85138532556&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FADCA9EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.exger.2022.111954 |
|---|