التفاصيل البيبلوغرافية
| العنوان: |
Evolution of innate immunity: lessons from mammalian models shaping our current view of insect immunity. |
| المؤلفون: |
Silva, Rafael Cardoso M. C.1 (AUTHOR) rcmcs@biof.ufrj.br, Ramos, Isabela B.2,3 (AUTHOR), Travassos, Leonardo H.1 (AUTHOR), Mendez, Ana Paula Guzman4 (AUTHOR), Gomes, Fabio M.3,4 (AUTHOR) fabiomg@biof.ufrj.br |
| المصدر: |
Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology. Apr2024, Vol. 194 Issue 2, p105-119. 15p. |
| مصطلحات موضوعية: |
*NATURAL immunity, *IMMUNITY, *INSECTS, *IMMUNE response, *IMMUNE system |
| مستخلص: |
The innate immune system, a cornerstone for organismal resilience against environmental and microbial insults, is highly conserved across the evolutionary spectrum, underpinning its pivotal role in maintaining homeostasis and ensuring survival. This review explores the evolutionary parallels between mammalian and insect innate immune systems, illuminating how investigations into these disparate immune landscapes have been reciprocally enlightening. We further delve into how advancements in mammalian immunology have enriched our understanding of insect immune responses, highlighting the intertwined evolutionary narratives and the shared molecular lexicon of immunity across these organisms. Therefore, this review posits a holistic understanding of innate immune mechanisms, including immunometabolism, autophagy and cell death. The examination of how emerging insights into mammalian and vertebrate immunity inform our understanding of insect immune responses and their implications for vector-borne disease transmission showcases the imperative for a nuanced comprehension of innate immunity's evolutionary tale. This understanding is quintessential for harnessing innate immune mechanisms' potential in devising innovative disease mitigation strategies and promoting organismal health across the animal kingdom. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
