An excreted small molecule promotes C. elegans reproductive development and aging
| العنوان: | An excreted small molecule promotes C. elegans reproductive development and aging |
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| المؤلفون: | Oishika Panda, Ilya Ruvinsky, Pooja Gudibanda, Erin Z. Aprison, Pedro R Rodrigues, Andreas H. Ludewig, Russell N. Burkhardt, Ying K. Zhang, Dania C. Pulido, Frank C. Schroeder, Alexander B. Artyukhin |
| المصدر: | Nature chemical biology |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Aging, Oviposition, media_common.quotation_subject, medicine.medical_treatment, Diapause, Article, 03 medical and health sciences, Hermaphrodite, biology.animal, medicine, Animals, Sexual maturity, Hermaphroditic Organisms, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Molecular Biology, 030304 developmental biology, media_common, 0303 health sciences, biology, 030302 biochemistry & molecular biology, Longevity, Gene Expression Regulation, Developmental, Vertebrate, Cell Biology, biology.organism_classification, Cell biology, Steroid hormone, Sex pheromone, Mutation, Signal Transduction |
| الوصف: | Excreted small-molecule signals can bias developmental trajectories and physiology in diverse animal species. However, the chemical identity of these signals remains largely obscure. Here we report identification of an unusual N-acylated glutamine derivative, nacq#1, that accelerates reproductive development and shortens lifespan in Caenorhabditis elegans. Produced predominantly by C. elegans males, nacq#1 hastens onset of sexual maturity in hermaphrodites by promoting exit from the larval dauer diapause and by accelerating late larval development. Even at picomolar concentrations, nacq#1 shortens hermaphrodite lifespan, suggesting a trade-off between reproductive investment and longevity. Acceleration of development by nacq#1 requires chemosensation and is dependent on three homologs of vertebrate steroid hormone receptors. Unlike ascaroside pheromones, which are restricted to nematodes, fatty acylated amino acid derivatives similar to nacq#1 have been reported from humans and invertebrates, suggesting that related compounds may serve signaling functions throughout metazoa. |
| تدمد: | 1552-4469 1552-4450 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bc77bc4c1c9c0358f2469917b3e2c7Test https://doi.org/10.1038/s41589-019-0321-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77bc77bc4c1c9c0358f2469917b3e2c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524469 15524450 |
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