التفاصيل البيبلوغرافية
| العنوان: |
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth |
| المؤلفون: |
Girchenko, Polina, Lahti, Jari, Czamara, Darina, Knight, Anna K., Jones, Meaghan J., Suarez Figueiredo, Anna, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M., Reynolds, Rebecca M., Kobor, Michael S., Smith, Alicia K., Binder, Elisabeth B., Räikkönen, Katri |
| المساهمون: |
Medicum, Department of Psychology and Logopedics, Helsinki Collegium for Advanced Studies, HUSLAB, Department of Clinical Chemistry and Hematology, Clinicum, Children's Hospital, Lastentautien yksikkö, Institute for Molecular Medicine Finland, Department of Medical and Clinical Genetics, Pregnancy and Genes, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Children and Adolescents, Developmental Psychology Research Group, Genomics of Neurological and Neuropsychiatric Disorders |
| بيانات النشر: |
BMC |
| سنة النشر: |
2017 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Aging, Cord blood methylation, Epigenetic clock, Gestational age, Prenatal programming, CORONARY-HEART-DISEASE, DNA METHYLATION, EARLY-LIFE, CHRONOLOGICAL AGE, ADULT DISEASE, HUMAN BRAIN, CELL-TYPES, BODY-MASS, COHORT, WEIGHT, Cancers |
| الوصف: |
Background: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage. Results: DNAm GA acceleration (GAA; i.e., older DNAm GA than chronological GA) of the offspring at birth was associated with maternal age of over 40 years at delivery, pre-eclampsia and fetal demise in a previous pregnancy, maternal pre-eclampsia and treatment with antenatal betamethasone in the index pregnancy, lower neonatal birth size, lower 1-min Apgar score, and female sex. DNAm GA deceleration (GAD; i.e., younger DNAm GA than chronological GA) of the offspring at birth was associated with insulin-treated gestational diabetes mellitus (GDM) in a previous pregnancy and Sjogren's syndrome. These findings were more accentuated when the DNAm GA calculation was based on the raw difference between DNAm GA and GA than on the residual from the linear regression of DNAm GA on GA. Conclusions: Our findings show that variations in the DNAm GA of the offspring at birth are associated with a number of maternal and offspring characteristics known to reflect exposure to prenatal environmental adversity. Future studies should be aimed at determining if this biological variation is predictive of developmental adversity. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
This work was supported by the Academy of Finland, EVO (a special state subsidy for health science research), and University of Helsinki Research Funds.; Girchenko , P , Lahti , J , Czamara , D , Knight , A K , Jones , M J , Suarez Figueiredo , A , Hämäläinen , E , Kajantie , E , Laivuori , H , Villa , P M , Reynolds , R M , Kobor , M S , Smith , A K , Binder , E B & Räikkönen , K 2017 , ' Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth ' , Clinical epigenetics , vol. 9 , 49 . https://doi.org/10.1186/s13148-017-0349-zTest; ORCID: /0000-0002-4310-5297/work/33744618; ORCID: /0000-0003-3124-3470/work/33744767; ORCID: /0000-0001-5935-2498/work/33744954; http://hdl.handle.net/10138/189039Test; 011da82b-a211-44df-bac5-e781366c717e; 85018383724; 000400790600001 |
| الإتاحة: |
http://hdl.handle.net/10138/189039Test |
| حقوق: |
unspecified ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.BE3D9124 |
| قاعدة البيانات: |
BASE |
