دورية أكاديمية
Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue
| العنوان: | Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue |
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| المؤلفون: | Martinet, Kim, Zita, Bloquet, Stéphane, Bourgeois, Christine |
| المساهمون: | Régulation de la réponse immune, infection VIH-1 et autoimmunité, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Animalerie centrale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported by the ANRS (Agence Nationale de la Recherche contre le SIDA et les hépatites C), la Fondation pour la Recherche Médicale (FRM) and benefited from donations of the CIC bank (Crédit Industriel et Commercial) and Pericles consulting group. |
| المصدر: | Immunity & Ageing ; https://inserm.hal.science/inserm-00991192Test ; Immunity & Ageing, 2014, 11 (1), pp.8 |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Immunology, T cell, T cell lymphopenia, T cell homeostasis, Immunosenescence, Ageing, Aging, Age, GALT, MALT, CD4 T cell lymphopenia, CD4 T cell homeostasi, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; Background CD4 T cell lymphopenia is an important T cell defect associated to ageing. Higher susceptibility to infections, cancer, or autoimmune pathologies described in aged individuals is thought to partly rely on T cell lymphopenia. We hypothesize that such diverse effects may reflect anatomical heterogeneity of age related T cell lymphopenia. Indeed, no data are currently available on the impact of ageing on T cell pool recovered from gut associated lymphoid tissue (GALT), a crucial site of CD4 T cell accumulation. Results Primary, secondary and tertiary lymphoid organs of C57BL/6 animals were analysed at three intervals of ages: 2 to 6 months (young), 10 to 14 months (middle-aged) and 22 to 26 months (old). We confirmed that ageing preferentially impacted CD4 T cell compartment in secondary lymphoid organs. Importantly, a different picture emerged from gut associated mucosal sites: during ageing, CD4 T cell accumulation was progressively developing in colon and small intestine lamina propria and Peyer's patches. Similar trend was also observed in middle-aged SJL/B6 F1 mice. Interestingly, an inverse correlation was detected between CD4 T cell numbers in secondary lymphoid organs and colonic lamina propria of C57BL/6 mice whereas no increase in proliferation rate of GALT CD4 T cells was detected. In contrast to GALT, no CD4 T cell accumulation was detected in lungs and liver in middle-aged animals. Finally, the concomitant accumulation of CD4 T cell in GALT and depletion in secondary lymphoid organs during ageing was detected both in male and female animals. Conclusions Our data thus demonstrate that T cell lymphopenia in secondary lymphoid organs currently associated to ageing is not sustained in gut or lung mucosa associated lymphoid tissues or non-lymphoid sites such as the liver. The inverse correlation between CD4 T cell numbers in secondary lymphoid organs and colonic lamina propria and the absence of overt proliferation in GALT suggest that marked CD4 T cell decay in secondary ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | inserm-00991192; https://inserm.hal.science/inserm-00991192Test; https://inserm.hal.science/inserm-00991192/documentTest; https://inserm.hal.science/inserm-00991192/file/1742-4933-11-8.pdfTest |
| الإتاحة: | https://inserm.hal.science/inserm-00991192Test https://inserm.hal.science/inserm-00991192/documentTest https://inserm.hal.science/inserm-00991192/file/1742-4933-11-8.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E9E4CEDF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |