Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study
| العنوان: | Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study |
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| المؤلفون: | Loeffen, R., Winckers, K., Ford, I., Jukema, J.W., Robertson, M., Stott, D.J., Spronk, H.M., Cate, H. ten, Lowe, G.D., PROSPER Study Grp |
| المساهمون: | Promovendi CD, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Interne Geneeskunde, Biochemie, MUMC+: MA Alg Interne Geneeskunde (9), RS: CARIM - R1 - Thrombosis and haemostasis, Onderwijsontw & Onderwijsresearch, RS: SHE - R1 - Research (OvO) |
| المصدر: | Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 70(8), 982-988. Oxford University Press Journal of Gerontology: Medical Sciences, 70(8), 982-988 |
| بيانات النشر: | Oxford University Press, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Risk, Aging, medicine.medical_specialty, Epidemiology, Coronary Disease, Cardiovascular, Thrombin, Clinical trials, Internal medicine, Humans, Medicine, Prospective Studies, Prospective cohort study, Stroke, Aged, Aged, 80 and over, business.industry, Vascular disease, Hazard ratio, medicine.disease, Blood, Coagulation, Cardiovascular Diseases, Physical therapy, Cardiology, Female, Geriatrics and Gerontology, business, Pravastatin, Biomarkers, medicine.drug |
| الوصف: | Background. Hypercoagulability may be an important contributor to the pathophysiology of atherosclerosis and atherothrombosis. As thrombin fulfills a central role in coagulation and links to several cellular mechanisms involved in arterial disease, we hypothesized that thrombin generation is associated with cardiovascular events in elderly patients. Methods. We studied the relationship between plasma thrombin generation and incident coronary heart disease (CHD) and stroke in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). From this multicenter prospective cohort, 4,932 samples of subjects (7082 years) with pre-existing vascular disease or risk factors were available for thrombin generation measurements. Results. Within the 3.2 years of follow-up incident stroke and CHD was observed in 227 and 545 subjects, respectively. Baseline thrombin generation was significantly decreased in subjects with incident stroke compared with subjects without: normalized peak height 71.1 +/- 40.8% versus 82.3 +/- 44.9%, p = .0002, and normalized endogenous thrombin potential 79.1 +/- 23.3% versus 87.0 +/- 24.8%, p |
| اللغة: | English |
| تدمد: | 1079-5006 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db22c5532f3845013dfa66c38c5810c6Test https://cris.maastrichtuniversity.nl/en/publications/c0b3f586-6010-46df-bc53-02bfc0f9c2c7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db22c5532f3845013dfa66c38c5810c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10795006 |
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