The neutrophil–lymphocyte ratio and locoregional melanoma: a multicentre cohort study
| العنوان: | The neutrophil–lymphocyte ratio and locoregional melanoma: a multicentre cohort study |
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| المؤلفون: | D Dewar, Michelle C. I. Lo, Alyss V. Robinson, Ryckie G. Wade, Marc Moncrieff, Claire Keeble, Owen Thornton, Howard Peach |
| المصدر: | Cancer Immunology, Immunotherapy |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Oncology, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Neutrophils, Neutrophil–lymphocyte ratio, Immunology, Sentinel lymph node, Kaplan-Meier Estimate, Cohort Studies, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Internal medicine, Humans, Immunology and Allergy, Medicine, Lymphocytes, Platelet–lymphocyte ratio, Stage (cooking), Melanoma, Aged, Neoplasm Staging, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, business.industry, Proportional hazards model, fungi, Biomarker, Odds ratio, Middle Aged, Sentinel node, medicine.disease, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Cutaneous melanoma, Female, Original Article, business, Lymphocyte–monocyte ratio, Cohort study |
| الوصف: | Objectives The neutrophil–lymphocyte ratio (NLR) is an inflammatory biomarker which is useful in cancer prognostication. We aimed to investigate the differences in baseline NLR between patients with localised and metastatic cutaneous melanoma and how this biomarker changed over time with the recurrence of disease. Methods This multicentre cohort study describes patients treated for Stage I–III cutaneous melanoma over 10 years. The baseline NLR was measured immediately prior to surgery and again at the time of discharge or disease recurrence. The odds ratios (OR) for sentinel node involvement are estimated using mixed-effects logistic regression. The risk of recurrence is estimated using multivariable Cox regression. Results Overall 1489 individuals were included. The mean baseline NLR was higher in patients with palpable nodal disease compared to those with microscopic nodal or localised disease (2.8 versus 2.4 and 2.3, respectively; p Conclusion The NLR is associated with the volume of melanoma at presentation and may predict occult sentinel lymph metastases. Further prospective work is required to investigate how NLR may be modelled against other clinicopathological variables to predict outcomes and to understand the temporal changes in NLR following surgery for melanoma. |
| تدمد: | 1432-0851 0340-7004 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa027d65cd4bdaed9ac4735a13e43fe5Test https://doi.org/10.1007/s00262-019-02478-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aa027d65cd4bdaed9ac4735a13e43fe5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320851 03407004 |
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