دورية أكاديمية
Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.
| العنوان: | Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study. |
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| المؤلفون: | Haeusler, Karl Georg, Kirchhof, Paulus, Michalski, Dominik, Kraft, Andrea, Rizos, Timolaos, Gröschel, Klaus, Thomalla, Götz, Nabavi, Darius G, Röther, Joachim, Laufs, Ulrich, Veltkamp, Roland, Heuschmann, Peter U, Kunze, Claudia, Endres, Matthias, Investigators, MonDAFIS, Bauerle, Michael, Besselmann, Michael, Büttner, T., Dem, Petra, Diekmann, Jens, Dietzel, Joanna, Dziewas, Rainer, Ehrlich, Sven, Tütüncü, Serdar, Evens, Annette, Gahn, Georg, Günther, Albrecht, Hamann, Gerhard F, Hartmann, Andreas, Harvey, Karen Louise, Heidenreich, Fedor, Helberg, T., Hobohm, Carsten, Hoffmann, F., Fiessler, Cornelia, Hoffmann, Olaf, Jungehulsing, Gerhard J, Kampschulte, Eva-Maria, Kraft, Peter, Krogias, Christos, Leinisch, Elke, Maschke, Matthias, Merkelbach, Stefan, Muehler, Johannes, Niehaus, Ludwig, Malsch, Carolin, Nören, Gesa, Oschmann, P., Palm, Frederick, Petzold, Gabor Claus Julius Peter, Pfeiler, Larissa, Pfeilschifter, Waltraud, Prince, Marie, Ringleb, Peter, Rosenkranz, Michael, Royl, Georg, Olma, Manuel C, Schnabel, Renate B, Schurig, Johannes, Steinbrecher, A., Stingele, Robert, Tanislav, Christian, Tyler, Louise, Urbanek, Christian, Jawad-Ul-Qamar, Muhammad, Krämer, Michael, Wachter, Rolf |
| المصدر: | The lancet / Neurology 20(6), 426 - 436 (2021). doi:10.1016/S1474-4422(21)00067-3 |
| بيانات النشر: | Lancet Publ. Group |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Aged, 80 and over, Atrial Fibrillation: diagnosis, Atrial Fibrillation: epidemiology, Atrial Fibrillation: physiopathology, Brain Ischemia: diagnosis, Brain Ischemia: epidemiology, Brain Ischemia: physiopathology, Electrocardiography: methods, Female, Humans, Ischemic Stroke: diagnosis, Ischemic Stroke: epidemiology, Ischemic Stroke: physiopathology, Male, Middle Aged, Monitoring, Physiologic: methods, Risk Factors |
| جغرافية الموضوع: | DE |
| الوصف: | Systematic electrocardiogram (ECG) monitoring improves detection of covert atrial fibrillation in stroke survivors but the effect on secondary prevention is unknown. We aimed to assess the effect of systematic ECG monitoring of patients in hospital on the rate of oral anticoagulant use after 12 months.In this investigator-initiated, randomised, open-label, parallel-group multicentre study with masked endpoint adjudication, we recruited patients aged at least 18 years with acute ischaemic stroke or transient ischaemic attack without known atrial fibrillation in 38 certified stroke units in Germany. Patients were randomly assigned (1:1) to usual diagnostic procedures for atrial fibrillation detection (control group) or additional Holter-ECG recording for up to 7 days in hospital (intervention group). Patients were stratified by centre using a random permuted block design. The primary outcome was the proportion of patients on oral anticoagulants at 12 months after the index event in the intention-to-treat population. Secondary outcomes included the number of patients with newly diagnosed atrial fibrillation in hospital and the composite of recurrent stroke, major bleeding, myocardial infarction, or death after 6 months, 12 months, and 24 months. This trial was registered with ClinicalTrials.gov, NCT02204267, and is completed and closed for participants.Between Dec 9, 2014, and Sept 11, 2017, 3465 patients were randomly assigned, 1735 (50·1%) to the intervention group and 1730 (49·9%) to the control group. Oral anticoagulation status was available in 2920 (84·3%) patients at 12 months (1484 [50·8%] in the intervention group and 1436 [49·2%] in the control group). For the primary outcome, at 12 months, 203 (13·7%) of 1484 patients in the intervention group versus 169 (11·8%) of 1436 in the control group were on oral anticoagulants (odds ratio [OR] 1·2 [95% CI 0·9-1·5]; p=0·13). Atrial fibrillation was newly detected in patients in hospital in 97 (5·8%) of 1714 in the intervention group versus 68 (4·0%) of 1717 in the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:34022169; info:eu-repo/semantics/altIdentifier/issn/1474-4422; info:eu-repo/semantics/altIdentifier/issn/1474-4465; https://pub.dzne.de/record/154672Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-00301%22Test |
| الإتاحة: | https://doi.org/10.1016/S1474-4422Test(21)00067-3 https://pub.dzne.de/record/154672Test https://pub.dzne.de/search?p=id:%22DZNE-2021-00301%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E8809A0C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |