Mapping white matter integrity in elderly people with HIV
| العنوان: | Mapping white matter integrity in elderly people with HIV |
|---|---|
| المؤلفون: | Nir, TM, Jahanshad, N, Busovaca, E, Wendelken, L, Nicolas, K, Thompson, PM, Valcour, VG |
| المصدر: | Human brain mapping, vol 35, iss 3 Nir, TM; Jahanshad, N; Busovaca, E; Wendelken, L; Nicolas, K; Thompson, PM; et al.(2014). Mapping white matter integrity in elderly people with HIV. Human Brain Mapping, 35(3), 975-992. doi: 10.1002/hbm.22228. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3xr338ffTest |
| بيانات النشر: | eScholarship, University of California, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, cognition, Aging, Anti-HIV Agents, Antiretroviral Therapy, HIV Infections, cART, Neuropsychological Tests, Corpus Callosum, Nerve Fibers, Leukoencephalopathies, Clinical Research, Behavioral and Social Science, Humans, 2.1 Biological and endogenous factors, Highly Active, Aetiology, Aged, Neurosciences, HIV, Experimental Psychology, Middle Aged, diffusion tensor imaging, Mental Health, Infectious Diseases, Neurological, Biomedical Imaging, HIV/AIDS, Female, Cognitive Sciences, Atrophy, Infection, brain integrity, white matter |
| الوصف: | People with HIV are living longer as combination antiretroviral therapy (cART) becomes more widely available. However, even when plasma viral load is reduced to untraceable levels, chronic HIV infection is associated with neurological deficits and brain atrophy beyond that of normal aging. HIV is often marked by cortical and subcortical atrophy, but the integrity of the brain's white matter (WM) pathways also progressively declines. Few studies focus on older cohorts where normal aging may be compounded with HIV infection to influence deficit patterns. In this relatively large diffusion tensor imaging (DTI) study, we investigated abnormalities in WM fiber integrity in 56 HIV+ adults with access to cART (mean age: 63.9 ± 3.7 years), compared to 31 matched healthy controls (65.4 ± 2.2 years). Statistical 3D maps revealed the independent effects of HIV diagnosis and age on fractional anisotropy (FA) and diffusivity, but we did not find any evidence for an age by diagnosis interaction in our current sample. Compared to healthy controls, HIV patients showed pervasive FA decreases and diffusivity increases throughout WM. We also assessed neuropsychological (NP) summary z-score associations. In both patients and controls, fiber integrity measures were associated with NP summary scores. The greatest differences were detected in the corpus callosum and in the projection fibers of the corona radiata. These deficits are consistent with published NP deficits and cortical atrophy patterns in elderly people with HIV. © 2013 Wiley Periodicals, Inc. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::36bafa7d9254c504abf54cb45fe522a7Test https://escholarship.org/uc/item/3xr338ffTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..36bafa7d9254c504abf54cb45fe522a7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |