دورية أكاديمية
أعرض في EDS

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

التفاصيل البيبلوغرافية
العنوان: Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
المؤلفون: Fox, ER, Young, JH, Li, Y, Dreisbach, AW, Keating, BJ, Musani, SK, Liu, K, Morrison, AC, Ganesh, S, Kutlar, A, Ramachandran, VS, Polak, JF, Fabsitz, RR, Dries, DL, Farlow, DN, Redline, S, Adeyemo, A, Hirschorn, JN, Sun, YV, Wyatt, SB, Penman, AD, Palmas, W, Rotter, JI, Townsend, RR, Doumatey, AP, Tayo, BO, Mosley, TH, Lyon, HN, Kang, SJ, Rotimi, CN, Cooper, RS, Franceschini, N, Curb, JD, Martin, LW, Eaton, CB, Kardia, SL, Taylor, HA, Caulfield, MJ, Ehret, GB, Johnson, T, International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Chakravarti, A, Zhu, X, Levy, D
المساهمون: Medical Research Council (MRC)
المصدر: 2284 ; 2273
بيانات النشر: Oxford University Press (OUP)
سنة النشر: 2011
المجموعة: Imperial College London: Spiral
مصطلحات موضوعية: Adult, African Americans, Aged, Blood Pressure, Cohort Studies, Diastole, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Hypertension, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Systole, International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS)
الوصف: The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide singlenucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P = 3.6 ×10-8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P = 4.7 × 10-8). The top IBC association for SBP was rs2012318 (P = 6.4 × 10-6)) near SLC25A42 and for DBP was rs2523586 (P = 1.3 3 10-6) near HLA-B. None of the top variants replicated in additional AA (n 5 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P = 0.009; TBX3-TBX5, P = 0.03; and CSK-ULK3, P = 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. The Author 2011. Published by Oxford University Press.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1460-2083
العلاقة: Human Molecular Genetics; http://hdl.handle.net/10044/1/28749Test; https://dx.doi.org/10.1093/hmg/ddr092Test; G0801056B; G0801056/1
DOI: 10.1093/hmg/ddr092
الإتاحة: https://doi.org/10.1093/hmg/ddr092Test
http://hdl.handle.net/10044/1/28749Test
حقوق: © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.orgTest/ licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
رقم الانضمام: edsbas.BE1B56DC
قاعدة البيانات: BASE
الوصف
تدمد:14602083
DOI:10.1093/hmg/ddr092