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1A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis
المؤلفون: Joseph M. Parker, Kevin R. Flaherty, Jon P. Fiening, Dewei She, Stephanie L. Roseti, Chris Kell, Ethan Grant, Tarik Haddad, Ian Glaspole, Lisa Lancaster
المصدر: American Journal of Respiratory and Critical Care Medicine. 197:94-103
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Maximum Tolerated Dose, Population, Critical Care and Intensive Care Medicine, Placebo, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, law.invention, 03 medical and health sciences, Idiopathic pulmonary fibrosis, FEV1/FVC ratio, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Clinical endpoint, Humans, education, Aged, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Antibodies, Monoclonal, Middle Aged, Prognosis, medicine.disease, Interim analysis, Idiopathic Pulmonary Fibrosis, Survival Rate, Treatment Outcome, 030104 developmental biology, 030228 respiratory system, Immunology, Patient Safety, business, Cell Adhesion Molecules, Biomarkers, Tralokinumab
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf536d6dcf5827b482582e9cc4012eefTest
https://doi.org/10.1164/rccm.201704-0784ocTest -
2
المؤلفون: Alan M. Carruthers, Darryl A. Knight, Milena S. Espindola, David M. Habiel, Elena Miranda, Richard N. Hanna, Ethan Grant, Hao Liu, Timothy Burwell, Arthur Lewis, Cory M. Hogaboam, Lynne Murray, Fernanda Pilataxi, Ana Camelo, Ana Lucia Coelho, Matthew J. Bell, Bethany B. Moore, Lori A. Clarke
المصدر: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, Cytoplasm, lcsh:Medicine, Datasets as Topic, Apoptosis, DNA Mismatch Repair, Mice, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, DNA Breaks, Double-Stranded, RNA, Small Interfering, lcsh:Science, Lung, Cellular localization, Mice, Knockout, Multidisciplinary, biology, Chemistry, respiratory system, Middle Aged, 3. Good health, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Female, Intracellular, medicine.medical_specialty, DNA damage, DNA repair, Respiratory Mucosa, Lung injury, Article, Cell Line, 03 medical and health sciences, Bleomycin, medicine, Extracellular, Animals, Humans, Aged, Clusterin, Gene Expression Profiling, lcsh:R, Epithelial Cells, Fibrosis, eye diseases, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, MSH2, Case-Control Studies, Cancer research, biology.protein, lcsh:Q, sense organs, Extracellular Space
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6249dbae7d6833ce5e2c2bb0c203ac15Test
http://europepmc.org/articles/PMC5684342Test