Intratympanic infliximab is a safe and effective rescue therapy for refractory immune-mediated hearing loss
| العنوان: | Intratympanic infliximab is a safe and effective rescue therapy for refractory immune-mediated hearing loss |
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| المؤلفون: | Lorena Sanz-López, Alfredo García-Fernández, David Varillas-Delgado, Nieves Mata-Castro |
| المصدر: | European Archives of Oto-Rhino-Laryngology. 277:393-400 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Hearing loss, Hearing Loss, Sensorineural, Administration, Oral, Azathioprine, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Prednisone, otorhinolaryngologic diseases, Humans, Medicine, Longitudinal Studies, Prospective Studies, 030223 otorhinolaryngology, Aged, Injection, Intratympanic, Absolute threshold of hearing, medicine.diagnostic_test, business.industry, Auditory Threshold, General Medicine, Middle Aged, Infliximab, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Anesthesia, Chronic Disease, Female, Neurosurgery, medicine.symptom, Audiometry, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | To determine the efficacy and safety of the intratympanic infiltration of infliximab at the hearing threshold of patients in follow-up for refractory immune-mediated hearing loss. 17 patients were collected with relapses, despite maintenance treatment with oral azathioprine associated or not with oral prednisone at low doses (between 5 and 7.5 ml/day) or refractory relapses to previous intratympanic corticoid treatment being 19 affected ears infiltrated. We measured the hearing threshold by Pure-Tone Average (PTA) 500–3000 Hz, 125–8000 Hz and 250–8000 Hz in pre-infiltration (baseline) and follow-up 3 weeks post-infiltration with auditory threshold at frequencies 125–8000 Hz. The average age was 50.68 years (±15.23 years). After the administration of intratympanic infliximab, an improvement of the hearing threshold was showed in the Pure-Tone Average (PTA) calculated at 500–3000 Hz (p = 0.004), 125–8000 Hz (p = 0.001) and 250–8000 Hz (p = 0.006). An immediate improvement in low frequencies also was observed: 125, 250 and 500 Hz (p = 0.009, p = 0.002 and p |
| تدمد: | 1434-4726 0937-4477 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bc36f93f64f8d100ec036d0104c2fbTest https://doi.org/10.1007/s00405-019-05716-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e3bc36f93f64f8d100ec036d0104c2fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14344726 09374477 |
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