التفاصيل البيبلوغرافية
| العنوان: |
New genetic loci link adipose and insulin biology to body fat distribution. |
| المؤلفون: |
Shungin, D., Winkler, T.W., Croteau-Chonka, D.C., Ferreira, T., Locke, A.E., Mägi, R., Strawbridge, R.J., Pers, T.H., Fischer, K., Justice, A.E., Workalemahu, T., Wu, J.M., Buchkovich, M.L., Heard-Costa, N.L., Roman, T.S., Drong, A.W., Song, C., Gustafsson, S., Day, F.R., Esko, T., Fall, T., Kutalik, Z., Luan, J., Randall, J.C., Scherag, A., Vedantam, S., Wood, A.R., Chen, J., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C.T., Schmidt, E.M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bragg-Gresham, J.L., Buyske, S., Demirkan, A., Ehret, G.B., Feitosa, M.F., Goel, A., Jackson, A.U., Johnson, T., Kleber, M.E., Kristiansson, K., Mangino, M., Mateo Leach, I., Medina-Gomez, C., Palmer, C.D., Pasko, D., Pechlivanis, S., Peters, M.J., Prokopenko, I., Stančáková, A., Ju Sung, Y., Tanaka, T., Teumer, A., Van Vliet-Ostaptchouk, J.V., Yengo, L., Zhang, W., Albrecht, E., Ärnlöv, J., Arscott, G.M., Bandinelli, S., Barrett, A., Bellis, C., Bennett, A.J., Berne, C., Blüher, M., Böhringer, S., Bonnet, F., Böttcher, Y., Bruinenberg, M., Carba, D.B., Caspersen, I.H., Clarke, R., Daw, E.W., Deelen, J., Deelman, E., Delgado, G., Doney, A.S., Eklund, N., Erdos, M.R., Estrada, K., Eury, E., Friedrich, N., Garcia, M.E., Giedraitis, V., Gigante, B., Go, A.S., Golay, A., Grallert, H., Grammer, T.B., Gräßler, J., Grewal, J., Groves, C.J., Haller, T., Hallmans, G., Hartman, C.A., Hassinen, M., Hayward, C., Heikkilä, K., Herzig, K.H., Helmer, Q., Hillege, H.L., Holmen, O., Hunt, S.C., Isaacs, A., Ittermann, T., James, A.L., Johansson, I., Juliusdottir, T., Kalafati, I.P., Kinnunen, L., Koenig, W., Kooner, I.K., Kratzer, W., Lamina, C., Leander, K., Lee, N.R., Lichtner, P., Lind, L., Lindström, J., Lobbens, S., Lorentzon, M., Mach, F., Magnusson, P.K., Mahajan, A., McArdle, W.L., Menni, C., Merger, S., Mihailov, E., Milani, L., Mills, R., Moayyeri, A., Monda, K.L., Mooijaart, S.P., Mühleisen, T.W., Mulas, A., Müller, G., Müller-Nurasyid, M., Nagaraja, R., Nalls, M.A., Narisu, N., Glorioso, N., Nolte, I.M., Olden, M., Rayner, N.W., Renstrom, F., Ried, J.S., Robertson, N.R., Rose, L.M., Sanna, S., Scharnagl, H., Scholtens, S., Sennblad, B., Seufferlein, T., Sitlani, C.M., Vernon Smith, A., Stirrups, K., Stringham, H.M., Sundström, J., Swertz, M.A., Swift, A.J., Syvänen, A.C., Tayo, B.O., Thorand, B., Thorleifsson, G., Tomaschitz, A., Troffa, C., van Oort, F.V., Verweij, N., Vonk, J.M., Waite, L.L., Wennauer, R., Wilsgaard, T., Wojczynski, M.K., Wong, A., Zhang, Q., Hua Zhao, J., Brennan, E.P., Choi, M., Eriksson, P., Folkersen, L., Franco-Cereceda, A., Gharavi, A.G., Hedman, Å.K., Hivert, M.F., Huang, J., Kanoni, S., Karpe, F., Keildson, S., Kiryluk, K., Liang, L., Lifton, R.P., Ma, B., McKnight, A.J., McPherson, R., Metspalu, A., Min, J.L., Moffatt, M.F., Montgomery, G.W., Murabito, J.M., Nicholson, G., Nyholt, D.R., Olsson, C., Perry, J.R., Reinmaa, E., Salem, R.M., Sandholm, N., Schadt, E.E., Scott, R.A., Stolk, L., Vallejo, E.E., Westra, H.J., Zondervan, K.T., GLGC, ICBP, Amouyel, P., Arveiler, D., Bakker, S.J., Beilby, J., Bergman, R.N., Blangero, J., Brown, M.J., Burnier, M., Campbell, H., Chakravarti, A., Chines, P.S., Claudi-Boehm, S., Collins, F.S., Crawford, D.C., Danesh, J., de Faire, U., de Geus, E.J., Dörr, M., Erbel, R., Eriksson, J.G., Farrall, M., Ferrannini, E., Ferrières, J., Forouhi, N.G., Forrester, T., Franco, O.H., Gansevoort, R.T., Gieger, C., Gudnason, V., Haiman, C.A., Harris, T.B., Hattersley, A.T., Heliövaara, M., Hicks, A.A., Hingorani, A.D., Hoffmann, W., Hofman, A., Homuth, G., Humphries, S.E., Hyppönen, E., Illig, T., Jarvelin, M.R., Johansen, B., Jousilahti, P., Jula, A.M., Kaprio, J., Kee, F., Keinanen-Kiukaanniemi, S.M., Kooner, J.S., Kooperberg, C., Kovacs, P., Kraja, A.T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Lakka, T.A., Langenberg, C., Le Marchand, L., Lehtimäki, T., Lyssenko, V., Männistö, S., Marette, A., Matise, T.C., McKenzie, C.A., McKnight, B., Musk, A.W., Möhlenkamp, S., Morris, A.D., Nelis, M., Ohlsson, C., Oldehinkel, A.J., Ong, K.K., Palmer, L.J., Penninx, B.W., Peters, A., Pramstaller, P.P., Raitakari, O.T., Rankinen, T., Rao, D.C., Rice, T.K., Ridker, P.M., Ritchie, M.D., Rudan, I., Salomaa, V., Samani, N.J., Saramies, J., Sarzynski, M.A., Schwarz, P.E., Shuldiner, A.R., Staessen, J.A., Steinthorsdottir, V., Stolk, R.P., Strauch, K., Tönjes, A., Tremblay, A., Tremoli, E., Vohl, M.C., Völker, U., Vollenweider, P., Wilson, J.F., Witteman, J.C., Adair, L.S., Bochud, M., Boehm, B.O., Bornstein, S.R., Bouchard, C., Cauchi, S., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Cooper, R.S., Dedoussis, G., Ferrucci, L., Froguel, P., Grabe, H.J., Hamsten, A., Hui, J., Hveem, K., Jöckel, K.H., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., März, W., Munroe, P.B., Njølstad, I., Oostra, B.A., Palmer, C.N., Pedersen, N.L., Perola, M., Pérusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T.E., Saleheen, D., Sinisalo, J., Slagboom, P.E., Snieder, H., Spector, T.D., Thorsteinsdottir, U., Stumvoll, M., Tuomilehto, J., Uitterlinden, A.G., Uusitupa, M., van der Harst, P., Veronesi, G., Walker, M., Wareham, N.J., Watkins, H., Wichmann, H.E., Abecasis, G.R., Assimes, T.L., Berndt, S.I., Boehnke, M., Borecki, I.B., Deloukas, P., Franke, L., Frayling, T.M., Groop, L.C., Hunter, D.J., Kaplan, R.C., O'Connell, J.R., Qi, L., Schlessinger, D., Strachan, D.P., Stefansson, K., van Duijn, C.M., Willer, C.J., Visscher, P.M., Yang, J., Hirschhorn, J.N., Zillikens, M.C., McCarthy, M.I., Speliotes, E.K., North, K.E., Fox, C.S., Barroso, I., Franks, P.W., Ingelsson, E., Heid, I.M., Loos, R.J., Cupples, L.A., Morris, A.P., Lindgren, C.M., Mohlke, K.L. |
| المساهمون: |
ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, GLGC, ICBP, Dastani, Z., Hivert, MF., Timpson, N., Perry, JR., Yuan, X., Scott, RA., Henneman, P., Heid, IM., Kizer, JR., Lyytikainen, LP., Fuchsberger, C., Tanaka, T., Morris, AP., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., Pankow, JS., Uh, HW., Wu, Y., Bidulescu, A., Rasmussen-Torvik, LJ., Greenwood, CM., Ladouceur, M., Grimsby, J., Manning, AK., Liu, CT., Kooner, J., Mooser, VE., Vollenweider, P., Kapur, KA., Chambers, J., Wareham, NJ., Langenberg, C., Frants, R., Willemsvan-vanDijk, K., Oostra, BA., Willems, SM., Lamina, C., Winkler, T., Psaty, BM., Tracy, RP., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, PP., Evans, DM., St Pourcain, B., Sattar, N., Wood, A., Bandinelli, S., Carlson, OD., Egan, JM., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, ML., Loo, BM., Harris, T., Garcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, HE., Deloukas, P., Katsareli, E., Couper, DJ., Duncan, BB., Kloppenburg, M., Adair, LS., Borja, JB., Wilson, JG., Musani, S., Guo, X., Johnson, T., Semple, R., Teslovich, TM., Allison, MA., Redline, S., Buxbaum, SG., Mohlke, KL., Meulenbelt, I. |
| المصدر: |
Nature, vol. 518, no. 7538, pp. 187-196 |
| سنة النشر: |
2015 |
| المجموعة: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: |
Adipocytes/metabolism, Adipogenesis/genetics, Adipose Tissue/metabolism, Age Factors, Body Fat Distribution, Body Mass Index, Continental Population Groups/genetics, Epigenesis, Genetic, Europe/ethnology, Female, Genome, Human/genetics, Genome-Wide Association Study, Humans, Insulin/metabolism, Insulin Resistance/genetics, Male, Models, Biological, Neovascularization, Physiologic/genetics, Obesity/genetics, Polymorphism, Single Nucleotide/genetics, Quantitative Trait Loci/genetics, Sex Characteristics, Transcription, Genetic/genetics, Waist-Hip Ratio |
| الوصف: |
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0028-0836 |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/25673412; info:eu-repo/semantics/altIdentifier/eissn/1476-4687; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_10C25BFE14DB2; https://serval.unil.ch/notice/serval:BIB_10C25BFE14DBTest; urn:issn:0028-0836; https://serval.unil.ch/resource/serval:BIB_10C25BFE14DB.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_10C25BFE14DB2Test |
| DOI: |
10.1038/nature14132 |
| الإتاحة: |
https://doi.org/10.1038/nature14132Test
https://serval.unil.ch/notice/serval:BIB_10C25BFE14DBTest
https://serval.unil.ch/resource/serval:BIB_10C25BFE14DB.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_10C25BFE14DB2Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimerTest |
| رقم الانضمام: |
edsbas.63B4CA86 |
| قاعدة البيانات: |
BASE |
