التفاصيل البيبلوغرافية
| العنوان: |
Host APOL1 genotype is independently associated with proteinuria in HIV infection |
| المؤلفون: |
Estrella, M. M., Wyatt, C. M., Pearce, C. L., Li, M., Shlipak, M. G., Aouizerat, B. E., Gustafson, Deborah, 1966, Cohen, M. H., Gange, S. J., Kao, W. H. L., Parekh, R. S. |
| المصدر: |
Kidney International. 84(4):834-840 |
| مصطلحات موضوعية: |
Infectious Medicine, Infektionsmedicin, genetic renal disease, HIV, kidney disease, proteinuria, antiretrovirus agent, acquired immune deficiency syndrome, adult, African American, age distribution, allele, APOL1 gene, article, controlled study, cross-sectional study, ethnic difference, female, gene, genetic association, genetic risk, genetic variability, genotype, glomerulus filtration rate, heterozygote, highly active antiretroviral therapy, host, human, Human immunodeficiency virus 1, Human immunodeficiency virus infection, hypertension, kidney dysfunction, major clinical study, medical history, Negro, priority journal, protein urine level, risk assessment, single nucleotide polymorphism, virus load |
| الوصف: |
Proteinuria is associated with adverse clinical outcomes in HIV infection. Here we evaluated whether APOL1 risk alleles, previously associated with advanced kidney disease, are independently associated with proteinuria in HIV infection in a cross-sectional study of HIV-infected women in the Women's Interagency HIV Study. We estimated the percent difference in urine protein excretion and odds of proteinuria (≥200 mg/g) associated with two versus one or no APOL1 risk allele using linear and logistic regression, respectively. Of 1285 women successfully genotyped, 379 carried one and 80 carried two risk alleles. Proteinuria was present in 124 women, 78 of whom had proteinuria confirmed on a second sample. In women without prior AIDS, two risk alleles were independently associated with a 69% higher urine protein excretion (95% confidence interval (CI): 36, 108) and five-fold higher odds of proteinuria (95% CI: 2.45, 10.37) as compared with one or no risk allele. No association was found in women with prior AIDS. Analyses in which women with impaired kidney function were excluded and proteinuria was confirmed by a second urine sample yielded similar estimates. Thus, APOL1 risk alleles are associated with significant proteinuria in HIV-infected persons without prior clinical AIDS, independent of clinical factors traditionally associated with proteinuria. Trials are needed to determine whether APOL1 genotyping identifies individuals who could benefit from earlier intervention to prevent overt renal disease. © 2013 International Society of Nephrology. |
| الوصول الحر: |
https://gup.ub.gu.se/publication/195492Test |
| قاعدة البيانات: |
SwePub |
