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1دورية أكاديمية
المؤلفون: Zhu, D, Chung, H-F, Dobson, AJ, Pandeya, N, Brunner, EJ, Kuh, D, Greenwood, DC, Hardy, R, Cade, JE, Giles, GG, Bruinsma, F, Demakakos, P, Simonsen, MK, Sandin, S, Weiderpass, E, Mishra, GD
المصدر: Human Reproduction , 35 (8) pp. 1933-1943. (2020)
مصطلحات موضوعية: HRT, age at menopause, cardiovascular disease, hazard ratio, natural menopause, pooled analysis, surgical menopause
الوصف: STUDY QUESTION: How does the risk of cardiovascular disease (CVD) vary with type and age of menopause? SUMMARY ANSWER: Earlier surgical menopause (e.g. <45 years) poses additional increased risk of incident CVD events, compared to women with natural menopause at the same age, and HRT use reduced the risk of CVD in women with early surgical menopause. WHAT IS KNOWN ALREADY: Earlier age at menopause has been linked to an increased risk of CVD mortality and all-cause mortality, but the extent that this risk of CVD varies by type of menopause and the role of postmenopausal HRT use in reducing this risk is unclear. STUDY DESIGN, SIZE, DURATION: Pooled individual-level data of 203 767 postmenopausal women from 10 observational studies that contribute to the International collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE) consortium were included in the analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS: Postmenopausal women who had reported menopause (type and age of menopause) and information on non-fatal CVD events were included. Type of menopause (natural menopause and surgical menopause) and age at menopause (categorised as <35, 35-39, 40-44, 45-49, 50-54 and ≥55 years) were exposures of interest. Natural menopause was defined as absence of menstruation over a period of 12 months (no hysterectomy and/or oophorectomy) and surgical menopause as removal of both ovaries. The study outcome was the first non-fatal CVD (defined as either incident coronary heart disease (CHD) or stroke) event ascertained from hospital medical records or self-reported. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% CI for non-fatal CVD events associated with natural menopause and surgical menopause. MAIN RESULTS AND THE ROLE OF CHANCE: Compared with natural menopause, surgical menopause was associated with over 20% higher risk of CVD (HR 1.22, 95% CI 1.16-1.28). After the stratified analysis by age at menopause, a graded relationship for incident CVD ...
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10103712/1/Types%20of%20menopause%20and%20CVD.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10103712Test/
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2دورية أكاديمية
المؤلفون: Zhu, D, Chung, H-F, Pandeya, N, Dobson, AJ, Hardy, R, Kuh, D, Brunner, EJ, Bruinsma, F, Giles, GG, Demakakos, P, Lee, JS, Mizunuma, H, Hayashi, K, Adami, H-O, Weiderpass, E, Mishra, GD
المصدر: European Journal of Epidemiology , 34 pp. 235-246. (2019)
مصطلحات موضوعية: Age at menopause, Cardiovascular disease, Pooled analysis, Premenopausal
الوصف: Early menopause is associated with an increased risk of subsequent cardiovascular disease (CVD). Few studies have investigated the converse. We examined whether premenopausal CVD events are associated with early age at menopause. We pooled the individual data of 177,131 women from nine studies. We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRR) and 95% confidence intervals (CI) for the associations between age at onset of premenopausal CVD events-including coronary heart disease (CHD) and stroke-and age at natural menopause. Altogether 1561 (0.9%) premenopausal participants reported CVD events (including 1130 CHD and 469 stroke) at a mean age of 41.3 years. Compared with women without any premenopausal CVD events, women who experienced a first CVD event before age 35 years had a twofold risk of menopause before age 45 years (early menopause); adjusted RRR (95% CI) of 1.92 (1.17, 3.14) for any CVD, 1.86 (1.01, 3.43) for CHD and 2.17 (1.43, 3.30) for stroke. Women who experienced a first premenopausal CVD event after age 40 years underwent a natural menopause at the expected age (around 51 years). These associations were robust to adjustment for smoking status, BMI, educational level, race/ethnicity, age at menarche, parity, hypertension and family history of CVD. For premenopausal women, a first CVD event before age 35 years is associated with a doubling of the risk of an early menopause, while a first CVD event occurred after 35 years indicates a normal menopause at around 51 years. Shared genetic and environmental factors (such as smoking), as well as compromised vasculature following CVD events, may contribute to this outcome.
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10067627/1/Demakakos_Premenopausal%20cardiovascular%20disease%20and%20age%20at%20natural%20menopause.%20A%20pooled%20analysis%20of%20over%20170,000%20women_AAM.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10067627Test/
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3دورية أكاديمية
المؤلفون: Zhu, D, Chung, H-F, Pandeya, N, Dobson, AJ, Kuh, D, Crawford, SL, Gold, EB, Avis, NE, Giles, GG, Bruinsma, F, Adami, H-O, Weiderpass, E, Greenwood, DC, Cade, JE, Mitchell, ES, Woods, NF, Brunner, EJ, Simonsen, MK, Mishra, GD
المصدر: European Journal of Epidemiology (2018) (In press).
مصطلحات موضوعية: Age at menopause, Obesity, Prospective studies, Underweight
الوصف: Current evidence on the association between body mass index (BMI) and age at menopause remains unclear. We investigated the relationship between BMI and age at menopause using data from 11 prospective studies. A total of 24,196 women who experienced menopause after recruitment was included. Baseline BMI was categorised according to the WHO criteria. Age at menopause, confirmed by natural cessation of menses for ≥ 12 months, was categorised as < 45 years (early menopause), 45-49, 50-51 (reference category), 52-53, 54-55, and ≥ 56 years (late age at menopause). We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRRs) and 95% confidence intervals (CI) for the associations between BMI and age at menopause. The mean (standard deviation) age at menopause was 51.4 (3.3) years, with 2.5% of the women having early and 8.1% late menopause. Compared with those with normal BMI (18.5-24.9 kg/m2), underweight women were at a higher risk of early menopause (RRR 2.15, 95% CI 1.50-3.06), while overweight (1.52, 1.31-1.77) and obese women (1.54, 1.18-2.01) were at increased risk of late menopause. Overweight and obesity were also significantly associated with around 20% increased risk of menopause at ages 52-53 and 54-55 years. We observed no association between underweight and late menopause. The risk of early menopause was higher among obese women albeit not significant (1.23, 0.89-1.71). Underweight women had over twice the risk of experiencing early menopause, while overweight and obese women had over 50% higher risk of experiencing late menopause.
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10049033/1/Kuh_BMI%20and%20age%20at%20menopause%20%28Clean%20Copy%29-Feb06-2018%20-Complete%20version1.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10049033Test/
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4دورية أكاديمية
المؤلفون: Zhu, D, Chung, H-F, Pandeya, N, Dobson, AJ, Hardy, R, Kuh, D, Brunner, EJ, Bruinsma, F, Giles, GG, Demakakos, P, Lee, JS, Mizunuma, H, Hayashi, K, Adami, H-O, Weiderpass, E, Mishra, GD
المصدر: European Journal of Epidemiology , 34 pp. 235-246. (2019) ; ftucl
مصطلحات موضوعية: Age at menopause, Cardiovascular disease, Pooled analysis, Premenopausal, psy, demo
الوصف: Early menopause is associated with an increased risk of subsequent cardiovascular disease (CVD). Few studies have investigated the converse. We examined whether premenopausal CVD events are associated with early age at menopause. We pooled the individual data of 177,131 women from nine studies. We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRR) and 95% confidence intervals (CI) for the associations between age at onset of premenopausal CVD events-including coronary heart disease (CHD) and stroke-and age at natural menopause. Altogether 1561 (0.9%) premenopausal participants reported CVD events (including 1130 CHD and 469 stroke) at a mean age of 41.3 years. Compared with women without any premenopausal CVD events, women who experienced a first CVD event before age 35 years had a twofold risk of menopause before age 45 years (early menopause); adjusted RRR (95% CI) of 1.92 (1.17, 3.14) for any CVD, 1.86 (1.01, 3.43) for CHD and 2.17 (1.43, 3.30) for stroke. Women who experienced a first premenopausal CVD event after age 40 years underwent a natural menopause at the expected age (around 51 years). These associations were robust to adjustment for smoking status, BMI, educational level, race/ethnicity, age at menarche, parity, hypertension and family history of CVD. For premenopausal women, a first CVD event before age 35 years is associated with a doubling of the risk of an early menopause, while a first CVD event occurred after 35 years indicates a normal menopause at around 51 years. Shared genetic and environmental factors (such as smoking), as well as compromised vasculature following CVD events, may contribute to this outcome.
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10067627/1/Demakakos_Premenopausal%20cardiovascular%20disease%20and%20age%20at%20natural%20menopause.%20A%20pooled%20analysis%20of%20over%20170,000%20women_AAM.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10067627Test/
