Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer?
| العنوان: | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
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| المؤلفون: | Agnieszka Walczyk, Danuta Gąsior-Perczak, Kinga Furga, Klaudia Gadawska-Juszczyk, Magdalena Chrapek, Aldona Kowalska, Jarosław Jaskulski, Artur Kuchareczko, Agnieszka Suligowska, Aleksandra Gajowiec, Estera Mikina, Anna Chromik, Alicja Skuza, Iwona Pałyga, Stanisław Góźdź, Monika Szymonek, Paweł Orłowski, Tomasz Trybek |
| المصدر: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2438, p 2438 (2021) Volume 10 Issue 11 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Response to therapy, endocrine system diseases, 030209 endocrinology & metabolism, risk stratification, Affect (psychology), Article, Papillary thyroid cancer, 03 medical and health sciences, 0302 clinical medicine, response to therapy, Internal medicine, medicine, papillary thyroid cancer, Risk factor, Lymph node, Angioinvasion, business.industry, male sex, Thyroid, General Medicine, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Risk stratification, Medicine, business |
| الوصف: | Identifying risk factors is crucial for predicting papillary thyroid cancer (PTC) with severe course, which causes a clinical problem. The purpose of this study was to assess whether male sex can be such a predictive factor and to verify whether including it as a predictive factor of high initial risk of recurrence/persistence would help to enhance the value of the American Thyroid Association initial risk stratification system (ATA). We retrospectively analyzed 1547 PTC patients (1358 females and 189 males), treated from 1986 to 2018. The relationship between sex and clinicopathological features, response to therapy, and disease status was assessed. Men with PTC showed some adverse clinicopathological features more often than women, including angioinvasion, lymph node metastases, and tumor size > 40 mm. There were sex-related disparities with respect to response to initial therapy and final follow-up. Male sex is associated with some unfavorable clinicopathological features of PTC, which may affect response to initial therapy or final disease status. In our study, modification of the ATA system by including male sex as a risk factor does not enhance its value. Thus, further studies are needed to assess whether males require treatment modalities or oncological follow-up protocols that are different from those of females. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b04eeae63b2d5ca9cf279855265a5aTest https://pubmed.ncbi.nlm.nih.gov/34072690Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....25b04eeae63b2d5ca9cf279855265a5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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