التفاصيل البيبلوغرافية
| العنوان: |
Injured recipients of low-titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: A single-center, retrospective study. |
| المؤلفون: |
Yazer, Mark H., Freeman, Andrew, Harrold, Ian M., Anto, Vincent, Neal, Matthew D., Triulzi, Darrell J., Sperry, Jason L., Seheult, Jansen N. |
| المصدر: |
Transfusion; Jun2021, Vol. 61 Issue 6, p1710-1720, 11p |
| مصطلحات موضوعية: |
TREATMENT effectiveness, ACUTE kidney failure, PROPENSITY score matching, NEONATAL sepsis, WOUND care, ABO blood group system, RESEARCH, BLOOD transfusion, RESEARCH methodology, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESUSCITATION, WOUNDS & injuries, BLOOD |
| مستخلص: |
Introduction: Low-titer group O whole blood (LTOWB) is being increasingly transfused to injured patients. This study evaluated a range of clinical outcomes to determine if receipt of LTOWB predisposed recipients to worse outcomes compared to recipients of conventional component therapy (CCT).Methods: A retrospective analysis of trauma patients who received at least 3 units of LTOWB (LTOWB group) versus those that received at least 3 units of RBCs, 1 unit of plasma and 1 unit of platelets but no LTOWB (CCT group) during the first 24 h of their admission was performed. Causal treatment effects were explored using propensity score matching (PSM) and coarsened exact matching (CEM). Important clinical outcomes were evaluated.Results: There were 165 CCT and 155 LTOWB recipients eligible for matching. PSM and CEM reduced covariate imbalances between the CCT and LTOWB groups, with the exception that males remained over-represented in the LTOWB group due to the hospital's former resuscitation policy of not administering RhD-positive LTOWB to females <50. In both of the matched analyses, the LTOWB group received a median of 4 LTOWB units. There were no significant differences in 6-, 24-h mortality or 30-day mortality between groups, nor were there differences in the frequency of other clinical outcomes such as acute kidney injury, sepsis, venous/arterial thromboembolism; delta MODS was lower for the LTOWB recipients in the exact match group.Conclusion: In both matched analyses, administration of a median of four LTOWB units did not result in a different frequency of major clinical outcomes including mortality. [ABSTRACT FROM AUTHOR] |
|
Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
