دورية أكاديمية
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy
| العنوان: | Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy |
|---|---|
| المؤلفون: | Naidoo, Jarushka, Wang, Xuan, Woo, Kaitlin M., Iyriboz, Tunc, Halpenny, Darragh, Cunningham, Jane, Chaft, Jamie E., Segal, Neil H., Callahan, Margaret K., Lesokhin, Alexander M., Rosenberg, Jonathan, Voss, Martin H., Rudin, Charles M., Rizvi, Hira, Hou, Xue, Rodriguez, Katherine, Albano, Melanie, Gordon, Ruth-Ann, Leduc, Charles, Rekhtman, Natasha, Harris, Bianca, Menzies, Alexander M., Guminski, Alexander D., Carlino, Matteo S., Kong, Benjamin Y., Wolchok, Jedd D., Postow, Michael A., Long, Georgina V., Hellmann, Matthew D. |
| المساهمون: | Hellmann, MD (reprint author), Mem Sloan Kettering Canc Ctr, 300 E 66th St, New York, NY 10065 USA., Mem Sloan Kettering Canc Ctr, 300 E 66th St, New York, NY 10065 USA., Weill Cornell Med Coll, New York, NY USA., Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Baltimore, MD USA., Peking Univ Canc Hosp & Inst, Beijing, Peoples R China., Sun Yat Sen Univ, Ctr Canc, Guangzhou, Guangdong, Peoples R China., Univ Sydney, Sydney, NSW, Australia., Royal North Shore & Mater Hosp, Melbourne, Vic, Australia., Westmead Hosp, Sydney, NSW, Australia., Blacktown Hosp, Sydney, NSW, Australia. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | JOURNAL OF CLINICAL ONCOLOGY |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | CELL LUNG-CANCER, INTERSTITIAL PNEUMONITIS, PULMONARY TOXICITY, ADVANCED MELANOMA, PD-1 BLOCKADE, NIVOLUMAB, DOCETAXEL, ANTI-PD-1, IMMUNOTHERAPY, PEMBROLIZUMAB |
| الوصف: | Purpose Pneumonitis is an uncommon but potentially fatal toxicity of anti-programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) monoclonal antibodies (mAbs). Clinical, radiologic, and pathologic features are poorly described. Methods Patients who received anti-PD-1/PD-L1 monotherapy or in combination with anti-cytotoxic T-cell lymphocyte-4 mAb were identified at two institutions (Memorial Sloan Kettering Cancer Center: advanced solid cancers, 2009 to 2014, and Melanoma Institute of Australia: melanomas only, 2013 to 2015). Pneumonitis was diagnosed by the treating investigator; cases with confirmed malignant lung infiltration or infection were excluded. Clinical, radiologic, and pathologic features of pneumonitis were collected. Associations among pneumonitis incidence, therapy received, and underlying malignancy were examined with Fisher's exact test as were associations between pneumonitis features and outcomes. Results Of 915 patients who received anti-PD-1/PD-L1 mAbs, pneumonitis developed in 43 (5%; 95% CI, 3% to 6%; Memorial Sloan Kettering Cancer Center, 27 of 578 [5%]; Melanoma Institute of Australia, 16 of 337 [5%]). Time to onset of pneumonitis ranged from 9 days to 19.2 months. The incidence of pneumonitis was higher with combination immunotherapy versus monotherapy (19 of 199 [10%] v 24 of 716 [3%]; P < .01). Incidence was similar in patients with melanoma and non-small-cell lung cancer (overall, 26 of 532 [5%] v nine of 209 [4%]; monotherapy, 15 of 417 v five of 152 [P = 1.0]; combination, 11 of 115 v four of 57 [P = .78]). Seventy-two percent (31 of 43) of cases were grade 1 to 2, and 86% (37 of 43) improved/resolved with drug holding/immunosuppression. Five patients worsened clinically and died during the course of pneumonitis treatment; proximal cause of death was pneumonitis (n = 1), infection related to immunosuppression (n = 3), or progressive cancer (n = 1). Radiologic and pathologic features of pneumonitis were diverse. Conclusion Pneumonitis associated with anti-PD-1/PD-L1 mAbs is ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0732-183X 1527-7755 |
| العلاقة: | JOURNAL OF CLINICAL ONCOLOGY.2017,35(7),709-+.; 1437739; http://hdl.handle.net/20.500.11897/492713Test; WOS:000396366100004 |
| DOI: | 10.1200/JCO.2016.68.2005 |
| الإتاحة: | https://doi.org/20.500.11897/492713Test https://doi.org/10.1200/JCO.2016.68.2005Test https://hdl.handle.net/20.500.11897/492713Test |
| رقم الانضمام: | edsbas.CE359C6F |
| قاعدة البيانات: | BASE |
| تدمد: | 0732183X 15277755 |
|---|---|
| DOI: | 10.1200/JCO.2016.68.2005 |