التفاصيل البيبلوغرافية
| العنوان: |
Human Coronavirus-HKU1 Infection Among Adults in Cleveland, Ohio. |
| المؤلفون: |
Kanwar, Anubhav, Selvaraju, Suresh, Esper, Frank |
| المصدر: |
Open Forum Infectious Diseases; Spring2017, Vol. 4 Issue 2, p1-6, 6p |
| مصطلحات موضوعية: |
CORONAVIRUS diseases, CORONAVIRUSES, RESPIRATORY infections |
| مستخلص: |
Background. Human coronaviruses (CoV) have been long recognized as a common cause of respiratory tract disease including severe respiratory tract illness. Coronavirus-HKU1 has been described predominantly among children less than 5 years of age in the United States with few studies characterizing the disease spectrum among adults. Methods. Nasopharyngeal specimens of patients with respiratory symptoms were analyzed for CoV-HKU1 by NxTAG Respiratory Pathogen Panel multiplex assay from February 7, 2016 to April 30, 2016. Epidemiologic, clinical, and laboratory data were collected on adults (patients >18 years) whose samples screened positive. Results. Of 832 adult respiratory specimens screened, 13 (1.6%) cases of CoV-HKU1 were identified. Adults age ranged between 23 and 75 years and 6 (46%) were males. All of whom had 1 or more respiratory symptoms, and 5 (38%) also reported 1 or more gastrointestinal symptoms. Eleven (85%) reported history of smoking and 5 (38%) used inhaled steroids. Seven (54%) required hospitalization, 5 (71%) of these needed supplemental oxygen, and 2 (29%) were admitted to intensive care. Median length of hospitalization was 5 days. Eight (62%) received antibiotics despite identification of CoV-HKU1. Infectious work-up in 1 patient who died did not reveal any other pathogen. In 2 (15%) CoV-HKU1-positive adults, the only viral coinfection detected was influenza A. Conclusions. Coronavirus-HKU1 accounted for 1.6% of adult respiratory infections and should be considered in differential diagnosis of severe respiratory illnesses among adults. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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