التفاصيل البيبلوغرافية
| العنوان: |
Evolving patterns of care and outcomes in relapsed/refractory FLT3 mutated acute myeloid leukemia adult patients. |
| المؤلفون: |
Boluda, Blanca, Martínez-Cuadrón, David, Algarra, Lorenzo, Cano, Isabel, Sayas, María J., Acuña-Cruz, Evelyn, Blanco, Albert, Marco-Ayala, Javier, DeLapuerta, Rosalía, Díaz-González, Álvaro, Tormo, Mar, Rodríguez-Veiga, Rebeca, García, Raimundo, Piñana, José L., López-Pavía, María, Barragán, Eva, Amigo, María L., Sargas, Claudia, López, Aurelio, Solana-Altabella, Antonio |
| المصدر: |
Leukemia & Lymphoma; Nov 2021, Vol. 62 Issue 11, p2727-2736, 10p |
| مصطلحات موضوعية: |
ACUTE myeloid leukemia, ADULTS, OVERALL survival, SURVIVAL rate, TREATMENT effectiveness |
| مستخلص: |
We have analyzed treatment patterns and outcomes of relapsed/refractory(R/R) FLT3mut AML adult patients registered in our institutional data base between 1998 and 2018. Overall, 147 patients were evaluable: 34 from 1998 to 2009, 113 from 2010 to 2018. Salvage treatments were intensive chemotherapy (n = 25, 74%), and supportive care (n = 9, 26%) in the 1998–2009 period, and intensive chemotherapy (n = 63, 56%), hypomethylating agent (n = 7, 6%), low-dose cytarabine-based (n = 8, 7%), clinical trial (n = 16, 14%) and supportive care (n = 19, 17%) in the 2010–2018 period. Complete remission (CR) or with incomplete recovery (CRi) rate was 44%, 49% among patients treated intensively (vs 30% with non-intensive p = 0.005). Median overall survival since first R/R was 5.8 months, and 16.3 months in subjects receiving an allo-HSCT in CR/CRi after first salvage (vs 3.8 in the remaining patients p < 0.0001). Clinical outcomes of R/R FLT3mut AML remain unsatisfactory. Inclusion in clinical trials and expanding options could lead to improved outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
