التفاصيل البيبلوغرافية
| العنوان: |
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age |
| المؤلفون: |
Humbert, Marion, Olofsson, Anna, Wullimann, David, Niessl, Julia, Hodcroft, Emma B., Cai, Curtis, Gao, Yu, Sohlberg, Ebba, Dyrdak, Robert, Mikaeloff, Flora, Neogi, Ujjwal, Albert, Jan, Malmberg, Karl-Johan, Lund-Johansen, Fridtjof, Aleman, Soo, Björkhem-Bergman, Linda, Jenmalm, Maria, Professor, 1971, Ljunggren, Hans-Gustaf, Buggert, Marcus, Karlsson, Annika C. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America. 120(12) |
| مصطلحات موضوعية: |
ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1, gamma interferon, interleukin 2, tumor necrosis factor, adult, adulthood, aged, Article, CD4+ T lymphocyte, cellular immunity, child, childhood, comorbidity, controlled study, coronavirus disease 2019, cross reaction, female, human, humoral immunity, major clinical study, male, memory T lymphocyte, nonhuman, protein expression, seroconversion, Severe acute respiratory syndrome coronavirus 2, virus nucleocapsid, virus spike |
| الوصف: |
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (β-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, Epstein–Barr virus (EBV), and influenza virus, which increased after age two. The quality of the memory CD4+ T cell responses peaked at age six and subsequently declined with age, with diminished expression of interferon (IFN)-γ, interleukin (IL)-2, tumor necrosis factor (TNF), and CD38 in late adulthood. Age-dependent qualitative differences in the pre-existing SARS-CoV-2-reactive T cell responses may reflect the ability of the host to control coronavirus infections and respond to vaccination. Copyright © 2023 the Author(s). |
| وصف الملف: |
print |
| الوصول الحر: |
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200780Test |
| قاعدة البيانات: |
SwePub |
