Rapid humoral immune responses are required for recovery from haemorrhagic fever with renal syndrome patients
| العنوان: | Rapid humoral immune responses are required for recovery from haemorrhagic fever with renal syndrome patients |
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| المؤلفون: | Lei Gao, Chuanmin Ma, Qian He, Michael J. Carr, Yuhai Bi, Hua Tang, Yaoni Li, Weijia Xing, Jiming Gao, Zhenjie Zhang, Chuansong Quan, Xiaolin Jiang, Peihan Wang, Weifeng Shi |
| المصدر: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunoglobulin gene, Adult, Male, China, Transcription, Genetic, Epidemiology, 030106 microbiology, Immunology, Down-Regulation, Receptors, Antigen, B-Cell, Antibodies, Viral, Microbiology, Serology, 03 medical and health sciences, Immune system, Virology, Drug Discovery, medicine, virus infection, Humans, Receptor, Hantaan virus, B cell, B-Lymphocytes, biology, business.industry, Sequence Analysis, RNA, breakpoint cluster region, General Medicine, Articles, Middle Aged, Haemorrhagic fever with renal syndrome, Immunity, Humoral, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Nucleoproteins, Hemorrhagic Fever with Renal Syndrome, biology.protein, Parasitology, Female, Antibody, business, humoral response, Research Article |
| الوصف: | Haemorrhagic fever with renal syndrome (HFRS) following Hantaan virus (HTNV) infection displays variable clinical signs. Humoral responses elicited during HTNV infections are considered important, however, this process remains poorly understood. Herein, we have investigated the phenotype, temporal dynamics, and characteristics of B-cell receptor (BCR) repertoire in an HFRS cohort. The serological profiles were characterized by a lowered expression level of nucleoprotein (NP)-specific antibody in severe cases. Importantly, B-cell subsets were activated and proliferated within the first two weeks of symptom onset and moderate cases reacted more rapidly. BCR analysis in the recovery phase revealed a dramatic increase in the immunoglobulin gene diversity which was more significantly progressed in moderate infections. In severe cases, B-cell-related transcription was lower with inflammatory sets overactivated. Taken together, these data suggest the clinical signs and disease recovery in HFRS patients were positively impacted by rapid and efficacious humoral responses. |
| اللغة: | English |
| تدمد: | 2222-1751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a19b11cb143eabb521682f36d700e7Test http://europepmc.org/articles/PMC8284976Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....22a19b11cb143eabb521682f36d700e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22221751 |
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