المؤلفون: Molveau, Joséphine, Rabasa-Lhoret, Rémi, Myette-Côté, Étienne, Messier, Virginie, Suppère, Corinne, J Potter, Kathryn, Heyman, Elsa, Tagougui, Sémah

المساهمون: Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 URePSSS, Institut de Recherches Cliniques de Montréal IRCM, Montreal Heart Institute - Institut de Cardiologie de Montréal

مصطلحات موضوعية: Adult, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Exercise, Female, Glucose, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Social Conditions, Young Adult, accelerometer, continous glucose monitoring, hypoglycemia, nocturnal glucose control, physical activity level, type 1 diabetes

الوصف: Studies investigating strategies to limit the risk of nocturnal hypoglycemia associated with physical activity (PA) are scarce and have been conducted in standardized, controlled conditions in people with type 1 diabetes (T1D). This study sought to investigate the effect of daily PA level on nocturnal glucose management in free-living conditions while taking into consideration reported mitigation strategies to limit the risk of nocturnal hyoglycemia in people with T1D. Data from 25 adults (10 males, 15 females, HbA: 7.6 ± 0.8%), 20-60 years old, living with T1D, were collected. One week of continuous glucose monitoring and PA (assessed using an accelerometer) were collected in free-living conditions. Nocturnal glucose values (midnight-6:00 am) following an active day "ACT" and a less active day "L-ACT" were analyzed to assess the time spent within the different glycemic target zones (10.0 mmol/L) between conditions. Self-reported data about mitigation strategies applied to reduce the risk of nocturnal hypoglycemia was also analyzed. Only 44% of participants reported applying a carbohydrate- or insulin-based strategy to limit the risk of nocturnal hypoglycemia on ACT day. Nocturnal hypoglycemia occurrences were comparable on ACT night versus on L-ACT night. Additional post-meal carbohydrate intake was higher on evenings following ACT (27.7 ± 15.6 g, ACT vs. 19.5 ± 11.0 g, L-ACT; P=0.045), but was frequently associated with an insulin bolus (70% of participants). Nocturnal hypoglycemia the night following ACT occurred mostly in people who administrated an additional insulin bolus before midnight (3 out of 5 participants with nocturnal hypoglycemia). Although people with T1D seem to be aware of the increased risk of nocturnal hypoglycemia associated with PA, the risk associated with additional insulin boluses may not be as clear. Most participants did not report using compensation strategies to reduce the risk of PA related late-onset hypoglycemia which may be because they did not consider habitual PA as something ...

وصف الملف: application/octet-stream; application/rdf+xml; charset=utf-8

العلاقة: Frontiers in Endocrinology; Front Endocrinol (Lausanne); http://hdl.handle.net/20.500.12210/79296Test

الإتاحة: https://doi.org/20.500.12210/79296Test
https://hdl.handle.net/20.500.12210/79296Test

المؤلفون: Leroux-Stewart, Josée, Elisha, Belinda, Tagougui, Sémah, Suppère, Corinne, Bernard, Sophie, Mircescu, Hortensia, Desjardin, Katherine, Messier, Virginie, Iacobellis, Gianluca, Rabasa-Lhoret, Rémi

المساهمون: Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Institut de Recherches Cliniques de Montréal IRCM, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369, University of Miami Leonard M. Miller School of Medicine UMMSM

مصطلحات موضوعية: Adiposity, Adult, Aged, Body Composition, Caloric Restriction, Cardiometabolic Risk Factors, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Male, Middle Aged, Pericardium, Pilot Projects, Quebec, Time Factors, Treatment Outcome, Cardiovascular risk factors, Energy restriction, Epicardial fat thickness, Structured exercise, Total fat mass, Type 2 diabetes

الوصف: There is debate over the independent and combined effects of caloric restriction (CR) and physical activity (PA) on reduction in fat mass and in epicardial fat thickness. We compared the impact of a similar energy deficit prescription by CR or by CR combined with PA on total fat mass, epicardial fat thickness, and cardiometabolic profile in individuals with type 2 diabetes. In this 16-week randomized controlled study, 73 individuals were randomly enrolled to receive: 1) a monthly motivational phone call (Control), 2) a caloric deficit of -700 kilocalories/day (CR), or 3) a caloric deficit of -500 kilocalories/day combined with a PA program of -200 kilocalories/day (CR&PA). Total fat mass, epicardial fat, and cardiometabolic profile were measured at baseline and after 16 weeks. While comparable weight loss occurred in both intervention groups (-3.9 ± 3.5 kg [CR], -5.1 ± 4.7 kg [CR&PA], -0.2 ± 2.9 kg [Control]), changes in total fat mass were significantly different between all groups (-2.4 ± 2.9 kg [CR], -4.5 ± 3.4 kg [CR&PA], +0.1 ± 2.1 kg [Control]; p < 0.05) as well as epicardial fat thickness (-0.4 ± 1.6 mm [CR], -1.4 ± 1.4 mm [CR&PA], +1.1 ± 1.3 mm [Control]; p < 0.05). There were no significant differences in trends for cardiometabolic parameters improvement between groups. For a similar energy deficit prescription and comparable weight loss, the combination of CR&PA provides a greater reduction in fat mass and epicardial fat thickness than CR alone in individuals with comparable weight loss and with a similar energy deficit prescription. These results, however, do not translate into significant improvements in cardiometabolic profiles. ; 31;3

العلاقة: Nutrition, metabolism, and cardiovascular diseases : NMCD; Nutr Metab Cardiovasc Dis; http://hdl.handle.net/20.500.12210/112536Test

الإتاحة: https://doi.org/20.500.12210/112536Test
https://hdl.handle.net/20.500.12210/112536Test

المؤلفون: Goulet-Gélinas, Lucas, Saade, Marie-Béatrice, Suppère, Corinne, Fortin, Andréanne, Messier, Virginie, Taleb, Nadine, Tagougui, Sémah, Shohoudi, Azadeh, Legault, Laurent, Henderson, Mélanie, Rabasa-Lhoret, Rémi

المساهمون: Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Université de Montréal UdeM, Institut de Recherches Cliniques de Montréal IRCM, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369, McGill University = Université McGill Montréal, Canada, Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital Montreal, Canada

مصطلحات موضوعية: Adolescent, Adult, Age Factors, Biomarkers, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 1, Dietary Carbohydrates, Exercise, Female, Glycated Hemoglobin, Glycemic Control, Humans, Hypoglycemia, Male, Middle Aged, Quebec, Time Factors, Treatment Outcome, Carbohydrate intake, Glycemic control & hypoglycemia, Physical activity, Type 1 diabetes

الوصف: During aerobic physical activity (PA), hypoglycemia is common in people with type 1 diabetes (T1D). Few studies have compared the effectiveness of different carbohydrate (CHO) intake strategies to prevent PA-induced hypoglycemia. Our objective was to compare the efficacy of two CHO intake strategies, same total amount but different CHO intake timing, to maintain glucose levels in the target range (4.0-10.0 mmol/L) during PA in people with T1D. An open-label, randomized, crossover study in 33 participants (21 adults; 12 adolescents). Participants practiced 60 min PA sessions (ergocyle) at 60% VO 3.5 h after lunch comparing an intake of 0.5 g of CHO per kg of body weight applied in a pre-PA single CHO intake (SCI) or in a distributed CHO intake (DCI) before and during PA. The percentage of time spent in glucose level target range during PA was not different between the two strategies (SCI: 75 ± 35%; DCI: 87 ± 26%; P = 0.12). Hypoglycemia (<4.0 mmol/L) occurred in 4 participants (12%) with SCI compared to 6 participants (18%) with DCI (P = 0.42). The SCI strategy led to a higher increase (P = 0.01) and variability of glucose levels (P = 0.04) compared with DCI. In people living with T1D, for a 60 min moderate aerobic PA in the post-absorptive condition, a 0.5 g/kg CHO intake helped most participants maintain acceptable glycemic control with both strategies. No clinically significant difference was observed between the SCI and DCI strategies. ; 31;4

العلاقة: Nutrition, metabolism, and cardiovascular diseases : NMCD; Nutr Metab Cardiovasc Dis; http://hdl.handle.net/20.500.12210/112537Test

الإتاحة: https://doi.org/20.500.12210/112537Test
https://hdl.handle.net/20.500.12210/112537Test

المؤلفون: Molveau, Joséphine, Rabasa-Lhoret, Rémi, Myette-Côté, Étienne, Messier, Virginie, Suppère, Corinne, J Potter, Kathryn, Heyman, Elsa, Tagougui, Sémah

المساهمون: Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Montreal Heart Institute - Institut de Cardiologie de Montréal

المصدر: ISSN: 1664-2392 ; Frontiers in Endocrinology ; https://hal.univ-lille.fr/hal-04040934Test ; Frontiers in Endocrinology, 2022, Frontiers in Endocrinology, 13, pp.953879. ⟨10.3389/fendo.2022.953879⟩.

مصطلحات موضوعية: Adult, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Exercise, Female, Glucose, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Social Conditions, Young Adult, accelerometer, continous glucose monitoring, nocturnal glucose control, physical activity level, type 1 diabetes, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Studies investigating strategies to limit the risk of nocturnal hypoglycemia associated with physical activity (PA) are scarce and have been conducted in standardized, controlled conditions in people with type 1 diabetes (T1D). This study sought to investigate the effect of daily PA level on nocturnal glucose management in free-living conditions while taking into consideration reported mitigation strategies to limit the risk of nocturnal hyoglycemia in people with T1D. Data from 25 adults (10 males, 15 females, HbA: 7.6 ± 0.8%), 20-60 years old, living with T1D, were collected. One week of continuous glucose monitoring and PA (assessed using an accelerometer) were collected in free-living conditions. Nocturnal glucose values (midnight-6:00 am) following an active day "ACT" and a less active day "L-ACT" were analyzed to assess the time spent within the different glycemic target zones (10.0 mmol/L) between conditions. Self-reported data about mitigation strategies applied to reduce the risk of nocturnal hypoglycemia was also analyzed. Only 44% of participants reported applying a carbohydrate- or insulin-based strategy to limit the risk of nocturnal hypoglycemia on ACT day. Nocturnal hypoglycemia occurrences were comparable on ACT night versus on L-ACT night. Additional post-meal carbohydrate intake was higher on evenings following ACT (27.7 ± 15.6 g, ACT vs. 19.5 ± 11.0 g, L-ACT; P=0.045), but was frequently associated with an insulin bolus (70% of participants). Nocturnal hypoglycemia the night following ACT occurred mostly in people who administrated an additional insulin bolus before midnight (3 out of 5 participants with nocturnal hypoglycemia). Although people with T1D seem to be aware of the increased risk of nocturnal hypoglycemia associated with PA, the risk associated with additional insulin boluses may not be as clear. Most participants did not report using compensation strategies to reduce the risk of PA related late-onset hypoglycemia which may be because they did not consider ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36237197; hal-04040934; https://hal.univ-lille.fr/hal-04040934Test; https://hal.univ-lille.fr/hal-04040934/documentTest; https://hal.univ-lille.fr/hal-04040934/file/2022_Molveau_Frontiers%20in%20Endocrinology.pdfTest; PUBMED: 36237197

الإتاحة: https://doi.org/10.3389/fendo.2022.953879Test
https://hal.univ-lille.fr/hal-04040934Test
https://hal.univ-lille.fr/hal-04040934/documentTest
https://hal.univ-lille.fr/hal-04040934/file/2022_Molveau_Frontiers%20in%20Endocrinology.pdfTest

المؤلفون: Molveau, Joséphine, Rabasa-Lhoret, Rémi, Myette-Côté, Étienne, Messier, Virginie, Suppère, Corinne, J Potter, Kathryn, Heyman, Elsa, Tagougui, Sémah

المساهمون: Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], Institut de Recherches Cliniques de Montréal [IRCM], Montreal Heart Institute - Institut de Cardiologie de Montréal, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM)

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, 2022, Frontiers in Endocrinology, 13, pp.953879. ⟨10.3389/fendo.2022.953879⟩

مصطلحات موضوعية: Adult, Blood Glucose, Male, type 1 diabetes, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, nocturnal glucose control, Hypoglycemia/chemically induced, Hypoglycemic Agents/adverse effects, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Exercise, Female, Glucose, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Middle Aged, Prevalence, Social Conditions, Young Adult, accelerometer, continous glucose monitoring, hypoglycemia, physical activity level, Insulin/adverse effects, Diabetes Mellitus, Type 1/complications

الوصف: ObjectiveStudies investigating strategies to limit the risk of nocturnal hypoglycemia associated with physical activity (PA) are scarce and have been conducted in standardized, controlled conditions in people with type 1 diabetes (T1D). This study sought to investigate the effect of daily PA level on nocturnal glucose management in free-living conditions while taking into consideration reported mitigation strategies to limit the risk of nocturnal hyoglycemia in people with T1D.MethodsData from 25 adults (10 males, 15 females, HbA1c: 7.6 ± 0.8%), 20-60 years old, living with T1D, were collected. One week of continuous glucose monitoring and PA (assessed using an accelerometer) were collected in free-living conditions. Nocturnal glucose values (midnight–6:00 am) following an active day “ACT” and a less active day “L-ACT” were analyzed to assess the time spent within the different glycemic target zones (10.0 mmol/L) between conditions. Self-reported data about mitigation strategies applied to reduce the risk of nocturnal hypoglycemia was also analyzed.ResultsOnly 44% of participants reported applying a carbohydrate- or insulin-based strategy to limit the risk of nocturnal hypoglycemia on ACT day. Nocturnal hypoglycemia occurrences were comparable on ACT night versus on L-ACT night. Additional post-meal carbohydrate intake was higher on evenings following ACT (27.7 ± 15.6 g, ACT vs. 19.5 ± 11.0 g, L-ACT; P=0.045), but was frequently associated with an insulin bolus (70% of participants). Nocturnal hypoglycemia the night following ACT occurred mostly in people who administrated an additional insulin bolus before midnight (3 out of 5 participants with nocturnal hypoglycemia).ConclusionsAlthough people with T1D seem to be aware of the increased risk of nocturnal hypoglycemia associated with PA, the risk associated with additional insulin boluses may not be as clear. Most participants did not report using compensation strategies to reduce the risk of PA related late-onset hypoglycemia which may be because they did not consider habitual PA as something requiring treatment adjustments.

وصف الملف: application/octet-stream; application/rdf+xml; charset=utf-8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a66c844970ee38e48f738d981f924fbTest
http://hdl.handle.net/20.500.12210/79296Test

المؤلفون: Tagougui, Semah, Legault, Laurent, Heyman, Elsa, Messier, Virginie, Suppere, Corinne, Potter, Kathryn J., Pigny, Pascal, Berthoin, Serge, Taleb, Nadine, Rabasa-Lhoret, Rémi

المساهمون: Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, McGill University = Université McGill [Montréal, Canada], Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 (MSAP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group

المصدر: Diabetes Technology and Therapeutics
Diabetes Technology and Therapeutics, 2022, Diabetes Technology and Therapeutics, 24 (5), ⟨10.1089/dia.2021.0375⟩

مصطلحات موضوعية: Adult, Blood Glucose, Cross-Over Studies, Adolescent, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Hypoglycemic Agents/therapeutic use, Blood Glucose/analysis, Hypoglycemia/etiology, Hypoglycemia, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Endocrinology, Insulin/therapeutic use, Humans, Hypoglycemic Agents, Insulin, Anticipated basal insulin reduction, Exercise-induced hypoglycemia, Insulin pump

الوصف: Objective: We investigated the effect of two key timings for basal insulin rate reduction on exercise-induced glucose changes and explored the association between circulating insulin concentrations and muscle vasoreactivity. Research Design and Methods: Twenty adults and adolescents performed 60-min exercise sessions (ergocycle) at 60% VO2peak, 240 min after a standardized lunch. In a randomized order, we compared an 80% basal insulin reduction applied 40 min (T-40) or 90 min (T-90) before exercise onset. Near-infrared spectroscopy was used to investigate muscle hemodynamics at vastus lateralis. Glucose and insulin plasma concentrations were measured. Results: Reduction in plasma glucose (PG) level during exercise was attenuated during T-90 versus T-40 strategy (-0.89 ± 1.89 mmol/L vs. -2.17 ± 2.49 mmol/L, respectively; P = 0.09). Linear mixed model analysis showed that PG dropped by an additional 0.01 mM per minute in T-40 versus T-90 (time × strategy interaction, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba6225a4c0d845eab1de3113f0e065eTest
https://hal.univ-lille.fr/hal-04105968Test