Vouga, Manon; Favre, Guillaume; Martinez-Perez, Oscar; Pomar, Leo; Acebal, Laura Forcen; Abascal-Saiz, Alejandra; Hernandez, Maria Rosa Vila; Hcini, Najeh; Lambert, Véronique; Carles, Gabriel; Sichitiu, Joanna; Salomon, Laurent; Stirnemann, Julien; Ville, Yves; de Tejada, Begoña Martinez; Goncé, Anna; Hawkins-Villarreal, Ameth; Castillo, Karen; Solsona, Eduard Gratacos; Trigo, Lucas; ... (2021). Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific reports, 11(1), p. 13898. Springer Nature 10.1038/s41598-021-92357-y <http://dx.doi.org/10.1038/s41598-021-92357-yTest> Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports SCIENTIFIC REPORTS r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease. ispartof: SCIENTIFIC REPORTS vol:11 issue:1 ispartof: location:England status: published
