Small Fiber Neuropathy in Patients with Chronic Pain and a Previous Diagnosis of Multiple Chemical Sensitivity Syndrome
| العنوان: | Small Fiber Neuropathy in Patients with Chronic Pain and a Previous Diagnosis of Multiple Chemical Sensitivity Syndrome |
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| المؤلفون: | Alex Incensi, Rocco Liguori, E. Fileccia, Damiano Galimberti, Vincenzo Donadio, Fabrizio Salvi, Giacomo Rao, Francesco Ventruto, Giovanni Rizzo |
| المساهمون: | Fileccia E., Incensi A., Ventruto F., Rizzo G., Galimberti D., Rao G., Salvi F., Liguori R., Donadio V. |
| المصدر: | Journal of Neuropathology & Experimental Neurology. 80:868-874 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Biopsy, Small Fiber Neuropathy, Chronic pain, Physical examination, Autonomic disorder, Gastroenterology, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Internal medicine, Skin biopsy, medicine, Humans, Skin, Multiple chemical sensitivity syndrome, Neurologic Examination, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Autonomic nervous system, Peripheral neuropathy, Neurology, Nerve conduction study, Female, Multiple Chemical Sensitivity, Neurology (clinical), business, Multiple chemical sensitivity, Human |
| الوصف: | Small fiber neuropathy (SFN) is characterized by the involvement of Aδ and C fibers leading to sensory, mainly pain, and/or autonomic symptoms. Multiple chemical sensitivity syndrome (MCS) is an incompletely defined condition characterized by the onset of various symptoms in patients after exposure to several chemical substances. Pain is a common symptom in these patients. In this study, we report the histological and clinical data of a cohort of 21 patients who had been diagnosed as having MCS and who were referred to us with the suspicion of SFN because of chronic pain. All patients underwent neurological clinical examination, (including scales for pain and autonomic disorders), and a skin biopsy. Age-matched healthy subjects were used as controls for the skin biopsies. Nerve conduction studies and serum screening to exclude possible causes of peripheral neuropathy were also performed. Skin biopsies disclosed a somatic SFN in all patients. Although the majority (18 out of 21) of patients also had autonomic symptoms. we found sparing of autonomic innervation in the biopsies. These observations suggest that chronic pain in MCS could be secondary to the presence of somatic SFN, although more data are needed to confirm these observations. |
| وصف الملف: | STAMPA |
| تدمد: | 1554-6578 0022-3069 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b144763093c76dc1b17f4982332b63acTest https://doi.org/10.1093/jnen/nlab082Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b144763093c76dc1b17f4982332b63ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15546578 00223069 |
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