Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria
| العنوان: | Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria |
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| المؤلفون: | Jessica Jellins, Tess Cruickshank, Manju Kandel, Damanpreet Garcha, Ciara Murphy, Carole Anne Whigham, Stephen Tong, Gabrielle Pell, Sebastian E. Illanes, Susan P. Walker, Jenny Myers, Emerson Keenan, Georgia P. Wong, Anna Middleton, Joshua Masci, Alexandra Roddy Mitchell, Natasha Pritchard, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino, Jon Hyett, Natalie J. Hannan, Tuong-Vi Nguyen, Teresa M. MacDonald, Manuel Schepeler, Elizabeth Murray, Fiona C Brownfoot, Jhy K. Nien |
| المصدر: | Garcha, D, Walker, S P, MacDonald, T M, Hyett, J, Jellins, J, Myers, J, Illanes, S E, Nien, J K, Schepeler, M, Keenan, E, Whigham, C-A, Cannon, P, Murray, E, Nguyen, T-V, Kandel, M, Masci, J, Murphy, C, Cruickshank, T, Pritchard, N, Hannan, N J, Brownfoot, F, Roddy Mitchell, A, Middleton, A, Pell, G, Wong, G P, Tong, S & Kaitu’u-Lino, T J 2021, ' Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria ', Scientific Reports, vol. 11, no. 1, 16595 . https://doi.org/10.1038/s41598-021-96077-1Test Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Placenta, Intrauterine growth restriction, Diseases, Pre-Eclampsia, Pregnancy, Metformin/pharmacology, Medicine, Birth Weight, Prospective cohort study, Multidisciplinary, Fetal Growth Retardation, Smoking, Organ Size, Hypertension/blood, Metformin, Cell Hypoxia, Mitochondria/drug effects, Mitochondria, Trophoblasts, Area Under Curve, Hypertension, embryonic structures, Infant, Small for Gestational Age, Smoking/blood, Gestation, Female, Adult, Science, Overweight/blood, Trophoblasts/enzymology, Gestational Age, Article, Preeclampsia, Andrology, Electron Transport, Fetal Growth Retardation/blood, Medical research, Placenta/metabolism, Humans, Syndecan-1/blood, Matrix Metalloproteinases/physiology, Fetus, business.industry, Case-control study, Infant, Newborn, Overweight, medicine.disease, Delivery, Obstetric, Pregnancy Complications/blood, Matrix Metalloproteinases, Pregnancy Complications, Diabetes, Gestational, Pre-Eclampsia/blood, ROC Curve, Small for gestational age, Syndecan-1, Diabetes, Gestational/blood, business, Biomarkers, Electron Transport/drug effects |
| الوصف: | Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomarkers may improve detection of pregnancies at risk. This study aimed to assess syndecan-1 as a biomarker for small for gestational age (SGA) or fetal growth restricted (FGR) pregnancies and determine its molecular regulation. Circulating maternal syndecan-1 was measured in several cohorts; a large prospective cohort collected around 36 weeks’ gestation (n = 1206), a case control study from the Manchester Antenatal Vascular service (285 women sampled at 24–34 weeks’ gestation); two prospective cohorts collected on the day of delivery (36 + 3–41 + 3 weeks’ gestation, n = 562 and n = 405 respectively) and a cohort who delivered for preterm FGR ( |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acf66776a728a419487abe22c6fb99cTest https://doi.org/10.1038/s41598-021-96077-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5acf66776a728a419487abe22c6fb99c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |